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Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry

Covalent Modifiers

Purkey, Yichin Liu, and Mark Merchant Analytical Chemistry 2023 DOI: 10.1021/acs.analchem.2c04417 Effective front-end sample preparation is critical for proteins extracted from tumors but is generally labor intensive and impractical for large sample numbers typical in pharmacodynamic (PD) studies.

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Embarking on a Career in Drug Development

Alta Sciences

Embarking on a Career in Drug Development nbartlett Tue, 08/29/2023 - 14:38 Getting to the Heart of Science with Amber malloy Amber Malloy, Altasciences At the heart of science are stories—stories of courage, challenges, successes, lessons, and people. They remind us of the immense benefits of drug development.

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Women in Stem with Dr Mrunal Jaywant

Drug Target Review

I started working as a trainee immediately after submitting my PhD thesis in Analytical chemistry to Pune university in India but initially felt immense pressure to prove myself, not only because I was a woman but also because there were very few PhD staff, in general.

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BioSpace Movers & Shakers, Nov. 6

The Pharma Data

Prior to that, Taveras was vice president of Small Molecule Drug Discovery and CMC Development at Biogen Idec, and Alantos Pharmaceuticals, which was acquired by Amgen in 2007. Prior to this, he held a position as a director of Analytical Chemistry in Drug Discovery at GlaxoSmithKline. from 1993 to 1995.