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Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry

Covalent Modifiers

Purkey, Yichin Liu, and Mark Merchant Analytical Chemistry 2023 DOI: 10.1021/acs.analchem.2c04417 Effective front-end sample preparation is critical for proteins extracted from tumors but is generally labor intensive and impractical for large sample numbers typical in pharmacodynamic (PD) studies.

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Women in Stem with Dr Mrunal Jaywant

Drug Target Review

I started working as a trainee immediately after submitting my PhD thesis in Analytical chemistry to Pune university in India but initially felt immense pressure to prove myself, not only because I was a woman but also because there were very few PhD staff, in general.

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BioSpace Movers & Shakers, Nov. 6

The Pharma Data

Horizon Therapeutics – Karin Rosén joined Ireland-based Horizon Therapeutics as executive vice president, research and development and chief scientific officer. Taveras will lead all research and non-clinical development functions supporting the company’s pipeline of investigational therapies. medical affairs at GlaxoSmithKline.