Broad Institute

JUNE 27, 2024

Unlike gene editing, this “epigenetic” editing does not modify the underlying DNA sequence, but it should switch the gene off permanently, which means that this could be a one-time treatment. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration.

Disease 142

Disease Therapies Clinical Trials Engineering 142

Codon

JULY 21, 2024

These rats, known as AA or P-lines, serve as animal models of alcoholism, exhibiting high alcohol-seeking behavior, withdrawal symptoms, and a predisposition to co-abuse ethanol and nicotine. Of course, AA and P-line rats are not the only research animals bred for the study of disease. It would be engineering,” he says.

Research 124

Research Engineering Disease Science 124

Drug Target Review

SEPTEMBER 10, 2024

To achieve an aggressive timeline from DNA to investigational new drug (IND) application, drug developers have strengthened collaborations with contract development & manufacturing organisations (CDMOs) to expedite drug development. FDA no longer has to require animal testing for new drugs. References: 1 Wadman M.

Drug Development 64

Drug Development Clinical Supply Production FDA 64

Codon

MARCH 14, 2023

The engineered T-cells were infused back into the rodents. A few days later, though, alarms: Animals with the modified T-cells had massive spikes in their cytokine levels, a sign that their b odies were under attack, crying out for help. had already done much the same T-cell engineering on 106 patients at the National Cancer Institute.

DNA 52

DNA Laboratories Engineering Animal Testing 52

Codon

NOVEMBER 1, 2024

Though my focus in this essay is narrow — I don’t discuss bottlenecks in clinical trials, human disease, or animal testing — I hope others will take on these challenges in similar essays. Perhaps you’ve seen this chart before, which shows the falling costs of DNA sequencing over the last two decades.

DNA 122

DNA RNA Molecular Biology Laboratories 122