Broad Institute

JUNE 27, 2024

Unlike gene editing, this “epigenetic” editing does not modify the underlying DNA sequence, but it should switch the gene off permanently, which means that this could be a one-time treatment. Like Cas9, ZFPs can serve as guide proteins to direct the tool to a target site in DNA.

Disease 142

Disease Therapies Engineering Clinical Trials 142

Codon

JULY 21, 2024

It may seem that if researchers are sufficiently concerned about the welfare of lab animals, the best thing to do would be to stop using animals altogether. However, a multitude of factors—from institutional inertia to a global animal-testing industry worth billions of dollars —make this outcome unlikely.

Research 113

Research Engineering Disease Science 113

Drug Target Review

SEPTEMBER 10, 2024

To achieve an aggressive timeline from DNA to investigational new drug (IND) application, drug developers have strengthened collaborations with contract development & manufacturing organisations (CDMOs) to expedite drug development. FDA no longer has to require animal testing for new drugs. References: 1 Wadman M.

Drug Development 64

Drug Development Clinical Supply Production Protein Expression 64

Codon

MARCH 14, 2023

Leave a comment Let Me Count the Reasons… The Bible of mouse caretaking is called the Guide for Care and Use of Laboratory Animals. Mice raised at five different animal facilities in Europe, under otherwise identical conditions , have “persistent differences in body weight” and behavior.

DNA 52

DNA Laboratories Engineering Animal Testing 52

Codon

NOVEMBER 1, 2024

” Nobody really knows without trying it out in the laboratory. Though my focus in this essay is narrow — I don’t discuss bottlenecks in clinical trials, human disease, or animal testing — I hope others will take on these challenges in similar essays. Subscribe to Asimov Press.

DNA 108

DNA RNA Molecular Biology Laboratories 108