Broad Institute

JUNE 27, 2024

Unlike gene editing, this “epigenetic” editing does not modify the underlying DNA sequence, but it should switch the gene off permanently, which means that this could be a one-time treatment. Like Cas9, ZFPs can serve as guide proteins to direct the tool to a target site in DNA.

Disease 142

Disease Therapies Engineering Clinical Trials 142

Drug Target Review

SEPTEMBER 10, 2024

To achieve an aggressive timeline from DNA to investigational new drug (IND) application, drug developers have strengthened collaborations with contract development & manufacturing organisations (CDMOs) to expedite drug development. FDA no longer has to require animal testing for new drugs. References: 1 Wadman M.

Drug Development 65

Drug Development Clinical Supply Production Protein Expression 65

Codon

MARCH 14, 2023

Mice raised at five different animal facilities in Europe, under otherwise identical conditions , have “persistent differences in body weight” and behavior. There are even differences in how their genomic DNA is packaged inside of neurons. DNA differences accumulate over generations of breeding.

DNA 52

DNA Laboratories Engineering Animal Testing 52