Remove Animal Testing Remove DNA Remove Trials
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A therapy candidate for fatal prion diseases turns off disease-causing gene

Broad Institute

Unlike gene editing, this “epigenetic” editing does not modify the underlying DNA sequence, but it should switch the gene off permanently, which means that this could be a one-time treatment. At first, they used part of a methyltransferase, a molecule that adds methyl groups to DNA, called DNMT3A.

Disease 142
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How Lume Whole Body Deodorant Was Inspired by a Genetic Disease

PLOS: DNA Science

Fishy Regulations Lume falls under the cosmetic category at FDA and so needn’t have undergone clinical trials, because it doesn’t treat an illness or condition. The chemo trial preceded Lume by more than a decade, so you’d think the product name would have been better researched. Remember the statins?

Disease 98
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Raising Welfare for Lab Rodents

Codon

It may seem that if researchers are sufficiently concerned about the welfare of lab animals, the best thing to do would be to stop using animals altogether. However, a multitude of factors—from institutional inertia to a global animal-testing industry worth billions of dollars —make this outcome unlikely.

Research 112
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Everything Wrong with Mouse Studies (Kinda)

Codon

The ALS Therapy Development Institute, located just ten minutes from my home in Cambridge, once tested more than 100 potential drugs to slow ALS progression in mice, all of which had been reported to be helpful in other studies. There are even differences in how their genomic DNA is packaged inside of neurons. Free-range mice?

DNA 52