Drug Target Review

JULY 6, 2023

Animal testing plays a significant role in pre-clinical research and therefore requires the use of millions of animals. million scientific procedures involving live animals were carried out in 2020. million scientific procedures involving live animals were carried out in 2020. In Britain, 2.88 In Britain, 2.88

Animal Testing 105

Animal Testing Drugs Clinical Trials Clinical Research 105

Broad Institute

JUNE 27, 2024

To deliver CHARM throughout the brain, the team collaborated with scientists in the lab of Ben Deverman , senior director of vector engineering at the Broad and a co-author of the study. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration. Online June 27, 2024.

Disease 142

Disease Therapies Clinical Trials Engineering 142

Drug Target Review

MARCH 18, 2024

These models can be used for more efficient and effective drug testing early in the development process, potentially reducing the need for animal testing and later-stage human trials that are both costly and time-consuming.

Marketing 59

Marketing Animal Testing Engineering Drug Development 59

Codon

JULY 21, 2024

These rats, known as AA or P-lines, serve as animal models of alcoholism, exhibiting high alcohol-seeking behavior, withdrawal symptoms, and a predisposition to co-abuse ethanol and nicotine. Of course, AA and P-line rats are not the only research animals bred for the study of disease. It would be engineering,” he says.

Research 119

Research Engineering Disease Science 119

FDA Law Blog: Biosimilars

OCTOBER 10, 2023

image artifacts), radiopacity testing or other suitable imaging compatibility testing for localization of a device, and assessment of risks associated with exposure of the implant to other imaging exams and radiotherapy devices, as appropriate.

FDA 45

FDA Animal Testing Engineering Regulations 45

Drug Target Review

SEPTEMBER 26, 2023

This shift occurred following implementation of the Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative in 2013 and extensive testing of hiPSC-cardiomyocytes with known proarrhythmic drugs. 1-4 This approach saves time, money, and resources, and ultimately leads to safer medicines going forward to the clinic.

Drugs 111

Drugs FDA Disease Animal Testing 111

Drug Target Review

SEPTEMBER 10, 2024

Advances in new technologies such as engineer transposase-based semi-targeted transgene integration, which integrates the genes of interest into highly active regions of the host genome, have enabled the generation of consistently and predictably high-yielding cell lines, as well as, supporting rapid stable pool generation.

Drug Development 64

Drug Development Clinical Supply Production FDA 64