Animal Testing, Engineering and Protein Expression

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Animal Testing

Engineering

Protein Expression

A therapy candidate for fatal prion diseases turns off disease-causing gene

Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. Previous research has shown that as little as 21 percent elimination of the protein can improve symptoms. Credit: Neumann EN, Bertozzi TM, et al.

Disease

Disease Therapies Engineering Clinical Trials

Rapid delivery of toxicological material

Drug Target Review

SEPTEMBER 10, 2024

Advances in new technologies such as engineer transposase-based semi-targeted transgene integration, which integrates the genes of interest into highly active regions of the host genome, have enabled the generation of consistently and predictably high-yielding cell lines, as well as, supporting rapid stable pool generation.

Drug Development

Drug Development Clinical Supply Production Protein Expression

Drug Discovery Digest

A therapy candidate for fatal prion diseases turns off disease-causing gene

Rapid delivery of toxicological material

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