Article - Drug Discovery Digest

Participants of pioneering CRISPR gene editing trial see vision improve

Science Daily: Pharmacology News

MAY 6, 2024

About 79% of clinical trial participants experienced measurable improvement after receiving experimental, CRISPR-based gene editing that is designed to fix a rare form of blindness, according to a new article.

Trials

Trials Clinical Trials

How to Configure ServiceNow Knowledge Articles for Microsoft Graph Connector

Perficient: Drug Development

JULY 2, 2024

If you use ServiceNow as your knowledge management platform, you might want to make your knowledge articles searchable and accessible from Microsoft Search. By connecting your ServiceNow knowledge articles to Microsoft Search, you can enable your users to find and request them directly from the Microsoft 365 apps.

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Will AI tools revolutionize public health? Not if they continue following old patterns, researchers argue

Science Daily: Pharmacology News

OCTOBER 8, 2024

A new article shares findings from an extensive literature analysis of AI's current trajectory in health care.

Research

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Can we live on our planet without destroying it?

Science Daily: Pharmacology News

NOVEMBER 13, 2024

A new article tackles these questions. How much land, water, and other resources does our lifestyle require? And how can we adapt this lifestyle to stay within the limits of what the Earth can give?

The evidence is mounting: humans were responsible for the extinction of large mammals

Science Daily: Pharmacology News

JULY 1, 2024

This conclusion comes from researchers who reviewed over 300 scientific articles from many different fields of research. Human hunting, not climate change, played a decisive role in the extinction of large mammals over the last 50,000 years.

Research

AI for real-time, patient-focused insight

Science Daily: Pharmacology News

NOVEMBER 4, 2024

This new study is described in the article as 'the first open-source and lightweight vision -- language foundation model, designed as a generalist capable of performing various biomedical tasks.' BiomedGPT is a new a new type of artificial intelligence (AI) designed to support a wide range of medical and scientific tasks.

Sharp look into Ockham's razor

Science Daily: Pharmacology News

JANUARY 28, 2025

A new article argues that by relying too much on parsimony in modeling, scientists make mistakes and miss opportunities.

Fine-tuned brain-computer interface makes prosthetic limbs feel more real

Science Daily: Pharmacology News

JANUARY 16, 2025

Two new articles document progress in neuroprosthetic technology that lets people feel the shape and movement of objects moving over the 'skin' of a bionic hand.

Research reveals the most complete dinosaur discovered in the UK in a century

Science Daily: Pharmacology News

JULY 10, 2024

The most complete dinosaur discovered in the UK in the last 100 years, with a pubic hip bone the size of a 'dinner plate', has been described in a new article.

Research

New JAMA Article Recommends Personal Drug Importation To Help American Patients Afford Prescription Drugs

Policy Prescription

OCTOBER 22, 2024

They offer this advice in a new article in the Journal of the American Medical Association. Article Review The article, Strategies to Help Patients Navigate High Prescription Drug Costs , offers very digestible and evidence-driven guidance for clinicians to better assist their patients with the tangled web of drug pricing in America.

Online Pharmacies

Online Pharmacies Pharmacy Drugs FDA Approval

How special is the Milky Way Galaxy?

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

The SAGA Survey just published three new research articles that provide us with new insights into the uniqueness of our own Milky Way Galaxy after completing the census of 101 satellite systems similar to the Milky Way's.

Research

The unintended consequences of success against malaria

Science Daily: Pharmacology News

JULY 23, 2024

The insecticide-treated bed nets and insecticide sprays that were so effective in preventing mosquito bites -- and therefore malaria -- are increasingly viewed as the causes of household pest resurgence after pests became resistant to pesticides, according to a new article.

Scientists untangle interactions between the Earth's early life forms and the environment over 500 million years

Science Daily: Pharmacology News

JULY 29, 2024

Now, an interdisciplinary team of scientists has produced a perspective article of this co-evolutionary history. The atmosphere, the ocean and life on Earth interacted over the past 500-plus million years in ways that improved conditions for early organisms to thrive.

Why the harsh Snowball Earth kick-started our earliest multicellular ancestors

Science Daily: Pharmacology News

JUNE 27, 2024

A new article shows how specific physical conditions -- especially ocean viscosity and resource deprivation -- during the global glaciation period known as Snowball Earth could have driven eukaryotes to turn multicellular.

'A hearty debate' concludes plant-based meat alternatives are healthier for your heart than meat

Science Daily: Pharmacology News

JUNE 25, 2024

A review article of the available studies directly comparing the impact of plant-based and animal-based meats consistently suggests that the plant-based alternatives improve cardiovascular risk factors.

1,2,3‐Triazole Tethered Spiro[Indoline‐Oxirane] Derivatives Induce Anticancer Effects in Human Hepatoma Cells

Chemical Biology and Drug Design

MARCH 26, 2025

In this article, we present the synthesis of novel 3-phenyl-1-((1-aryl-1 H -1,2,3-triazol-5-yl)methyl)spiro[indoline-3,2-oxiran]-2-one derivatives by the regioselective reaction of sulfur ylides with 1,2,3-triazole-tethered isatins and their anticancer effects on hepatocellular carcinoma (HCC) cells HepG2 and HCCLM3.

Research

Evaluating the truthfulness of fake news through online searches increases the chances of believing misinformation

Science Daily: Pharmacology News

DECEMBER 20, 2023

But a new study by a team of researchers shows the opposite occurs: Searching to evaluate the truthfulness of false news articles actually increases the probability of believing misinformation. Conventional wisdom suggests that searching online to evaluate the veracity of misinformation would reduce belief in it.

Research

Vacations are good for employee well-being, and the effects are long lasting

Science Daily: Pharmacology News

JANUARY 27, 2025

But you might want to change that if you want to improve your health and well-being, according to a new review article. Even if you did, it's highly likely you didn't fully unplug while off the clock.

New wound healing research produces full thickness human bioprinted skin

Science Daily: Pharmacology News

OCTOBER 4, 2023

A research article presents a significant breakthrough in the area of skin regeneration and wound healing.

Research

Study hints at the existence of the closest black holes to Earth in the Hyades star cluster

Science Daily: Pharmacology News

SEPTEMBER 8, 2023

A new article hints at the existence of several black holes in the Hyades cluster -- the closest open cluster to our solar system -- which would make them the closest black holes to Earth ever detected.

New research explains 'Atlantification' of the Arctic Ocean

Science Daily: Pharmacology News

SEPTEMBER 1, 2023

The many environmental responses to the Arctic dipole are described in a recent article. The findings indicate that stronger declines in sea ice will occur when an atmospheric feature known as the Arctic dipole reverses itself in its recurring cycle. This analysis helps explain how North Atlantic water influences Arctic Ocean climate.

Research

Research International

New and highly infectious E. coli strain resistant to powerful antibiotics

Science Daily: Pharmacology News

JANUARY 31, 2024

coli is described in a new article. A new type of E. coli that is both highly infectious and resistant to some antibiotics has been discovered. The newly identified mutation of antibiotic-resistant E. The team suggests that some existing antibiotics called carbapenems will be ineffective against the bacteria.

Optimizing Generic Drug Development with Machine Learning

Drug Patent Watch

DECEMBER 4, 2024

This article will explore how machine learning can be leveraged to optimize generic drug development… Source These methods have the potential to revolutionize the drug discovery process by enhancing the efficiency and accuracy of identifying and developing new drug candidates.

Drug Development

Drug Development Drugs Pharmaceuticals

Allergy study on 'wild' mice challenges the hygiene hypothesis

Science Daily: Pharmacology News

SEPTEMBER 29, 2023

Now, an article challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than 'clean' laboratory mice.

Immune Response

Immune Response Laboratories

Whales Around the World Play With Kelp Clumps

Science Daily: Pharmacology News

SEPTEMBER 27, 2023

A new article has analyzed another understudied behavior in baleen (filter-feeding) whales such as humpback whales in different populations across the northern and southern hemispheres. They appeared to roll around and 'play' with clumps of kelp and seaweed at the water's surface.

Research

Managing Drug Patent Portfolios Effectively

Drug Patent Watch

NOVEMBER 11, 2024

This article explores key best practices and strategies for optimizing drug patent… Source Effective management of drug patent portfolios is crucial for pharmaceutical companies to maintain market exclusivity, protect revenue streams, and drive innovation.

Pharmaceutical Companies

Pharmaceutical Companies Drugs Pharmaceuticals Marketing

Handling Drug Patent Invalidity Claims

Drug Patent Watch

DECEMBER 8, 2024

In this article, we will delve into the strategies and considerations for handling drug patent… Source However, with the increasing competition from generic and biosimilar manufacturers, patent invalidity claims have become a significant challenge for pharmaceutical companies.

No scientific evidence for cognitively advanced behaviors and symbolism by Homo naledi

Science Daily: Pharmacology News

NOVEMBER 13, 2023

Recent articles suggested the recent excavations at the Rising Star Cave system provided evidence of at least three burial features, two in the Dinaledi Chamber and a third in the Hill Antechamber cavity.

Science

RETURN TO ARTICLES ASAPPREVARTICLENEXT N-Acyl-N-Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A2B Receptor as Case Study

Covalent Modifiers

JUNE 29, 2024

Beerkens, Vasiliki Andrianopoulou, Xuesong Wang, Rongfang Liu, Gerard J. van Westen, Willem Jespers, Adriaan P. IJzerman, Laura H. Heitman, and Daan van der Es ACS Chemical Biology 2024 DOI: 10.1021/acschembio.4c00210 4c00210 Small molecular tool compounds play an essential role in the study of G protein-coupled receptors (GPCRs).

What Are Back Spasms, and Can They Be Treated?

Drugs.com

JUNE 21, 2023

This article will explore the causes of back spasms, their symptoms and, most. WEDNESDAY, June 21, 2023 -- "Oh, my aching back!" Everyone has uttered these words at some point, in response to the sharp, sudden pain that comes with back spasms.

Nitrogen?containing heterocyclic compounds: A ray of hope in depression?

Chemical Biology and Drug Design

FEBRUARY 15, 2024

This article highlights the various structural features along with the structure–activity relationship (SAR) of nitrogen-containing heterocyclics that play a key role in binding at target sites for potential antidepressant action.

Drugs

Drugs Research

Wastewater pipe dig reveals 'fossil treasure trove'

Science Daily: Pharmacology News

AUGUST 28, 2023

A new article describes the 266 fossil species as one of the richest and most diverse groups of three-million-year-old fauna ever found in New Zealand. At least ten previously unknown species will be described and named in future research.

Treatment

Treatment Research

Nuclear Receptors: A new mode of inhibition

Covalent Modifiers

SEPTEMBER 22, 2024

link] The article presents the discussion on interaction of covalent inhibitors GW9662 and T0070907 with the peroxisome proliferator-activated receptor gamma (PPARγ), revealing new insights into how these compounds influence receptor activity. Andrew D Huber, Taosheng Chen eLife 2024, 13 :e101446.

Regulations

Catalytic Protein Inhibitors

Covalent Modifiers

JANUARY 13, 2024

This article discusses the genesis of the burgeoning field of catalytic inhibitors, the current state of the art, and exciting future directions.

Small Molecule

Small Molecule International Disease Drugs

Researchers make a quantum computing leap with a magnetic twist

Science Daily: Pharmacology News

JUNE 27, 2023

In a pair of articles, they report that, in experiments with flakes of semiconductor materials -- each only a single layer of atoms thick -- they detected signatures of 'fractional quantum anomalous Hall' (FQAH) states. Scientists and engineers have announced a significant advancement in developing fault-tolerant qubits for quantum computing.

Research

Research Engineering

Phase III is Coming!

Drug Hunter

OCTOBER 5, 2023

With thousands of articles now, many of you have mentioned wanting to see more examples from previous coverage. Super Search A common complaint about this version of the site was the difficulty in searching for articles. “CYP induction”).

Trials

Trials Drugs

Streamlining the Generic Drug Supply Chain: Best Practices

Drug Patent Watch

FEBRUARY 10, 2025

Read the full article on streamlining the generic drug supply chain best practices: [link] By working together, manufacturers, distributors, and regulators can create a more efficient and patient-centric generic drug supply chain. What do you think is the biggest challenge facing the generic drug supply chain today?

Drugs

Drugs Regulations Production

Molecules on the Move: April ’23

Drug Hunter

MAY 31, 2023

This article compiles 20+ recent small molecules of general interest in the news in April 2023, with structures where they are available.

Small Molecule

Small Molecule Clinical Trials Trials Drugs

When Does Menopause Start? What to Expect at Any Age

Drugs.com

JUNE 22, 2023

This article will tell. THURSDAY, June 22, 2023 -- Menopause is a natural phase in a woman’s life. If you suspect you are experiencing symptoms, you may wonder at what age does menopause start. Typically, it occurs between 45 and 55 years of age.

Using Drug Patents to Block Competitors: The Tactics and Consequences

Drug Patent Watch

FEBRUARY 11, 2025

Read the full article here What do you think? Should companies be allowed to use drug patents to block competitors, or is this a barrier to innovation? Share your thoughts in the comments below.

Drugs

Drugs Treatment Marketing Production

The designation, synthesis, and affinity determination of affinity peptide for anthrax protective antigen

Chemical Biology and Drug Design

JUNE 7, 2023

This article utilized template-based molecular docking of peptides and receptors to identify six highly valuable mutation sites. Subsequent amino acid multi-site mutations were conducted to establish a virtual polypeptide library.

Treatment

Treatment Research

Olivia Munn Underwent Hysterectomy After Breast Cancer Diagnosis

Drugs.com

MAY 13, 2024

In an article published on Mother's Day, Munn told Vogue she opted for. MONDAY, May 13, 2024 -- Actress and "X-men" star Olivia Munn has revealed that she underwent egg retrieval and then a hysterectomy after being diagnosed with breast cancer.

Molecules of the Month – August 2023

Drug Hunter

SEPTEMBER 17, 2023

We’ll have more detailed case studies on these molecules coming soon, but in the meantime you can check out some recent articles about the following here: VX-548 – oral NaV1.8 III clinical trials such as Vertex’s sodium channel inhibitor for acute pain and Denali Therapeutics’ CNS-penetrant eIF2B activator for ALS.

Clinical Trials

Clinical Trials Trials Therapies Pharmaceuticals

Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry

Covalent Modifiers

OCTOBER 3, 2023

Gray Journal of the American Chemical Society Article ASAP DOI: 10.1021/jacs.3c06622 Donovan, Pooreum Seo, Martha Ordonez, Woong Sub Byun, Muhammad Murtaza Hassan, Franziska Wachter, Edward T. Chouchani, Mikołaj Słabicki, Eric S. Fischer, Benjamin L. Ebert, Stephen M. Hinshaw, and Nathanael S.

Targeted Protein Degradation

Targeted Protein Degradation Small Molecule Drugs

Participants of pioneering CRISPR gene editing trial see vision improve

How to Configure ServiceNow Knowledge Articles for Microsoft Graph Connector

Webinars

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Will AI tools revolutionize public health? Not if they continue following old patterns, researchers argue

Webinars

Can we live on our planet without destroying it?

The evidence is mounting: humans were responsible for the extinction of large mammals

AI for real-time, patient-focused insight

Sharp look into Ockham's razor

Fine-tuned brain-computer interface makes prosthetic limbs feel more real

Research reveals the most complete dinosaur discovered in the UK in a century

New JAMA Article Recommends Personal Drug Importation To Help American Patients Afford Prescription Drugs

How special is the Milky Way Galaxy?

The unintended consequences of success against malaria

Scientists untangle interactions between the Earth's early life forms and the environment over 500 million years

Why the harsh Snowball Earth kick-started our earliest multicellular ancestors

'A hearty debate' concludes plant-based meat alternatives are healthier for your heart than meat

1,2,3‐Triazole Tethered Spiro[Indoline‐Oxirane] Derivatives Induce Anticancer Effects in Human Hepatoma Cells

Evaluating the truthfulness of fake news through online searches increases the chances of believing misinformation

Vacations are good for employee well-being, and the effects are long lasting

New wound healing research produces full thickness human bioprinted skin

Study hints at the existence of the closest black holes to Earth in the Hyades star cluster

New research explains 'Atlantification' of the Arctic Ocean

New and highly infectious E. coli strain resistant to powerful antibiotics

Optimizing Generic Drug Development with Machine Learning

Allergy study on 'wild' mice challenges the hygiene hypothesis

Whales Around the World Play With Kelp Clumps

Managing Drug Patent Portfolios Effectively

Handling Drug Patent Invalidity Claims

No scientific evidence for cognitively advanced behaviors and symbolism by Homo naledi

RETURN TO ARTICLES ASAPPREVARTICLENEXT N-Acyl-N-Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A2B Receptor as Case Study

What Are Back Spasms, and Can They Be Treated?

Nitrogen?containing heterocyclic compounds: A ray of hope in depression?

Wastewater pipe dig reveals 'fossil treasure trove'

Nuclear Receptors: A new mode of inhibition

Catalytic Protein Inhibitors

Researchers make a quantum computing leap with a magnetic twist

Phase III is Coming!

Streamlining the Generic Drug Supply Chain: Best Practices

Molecules on the Move: April ’23

When Does Menopause Start? What to Expect at Any Age

Using Drug Patents to Block Competitors: The Tactics and Consequences

The designation, synthesis, and affinity determination of affinity peptide for anthrax protective antigen

Olivia Munn Underwent Hysterectomy After Breast Cancer Diagnosis

Molecules of the Month – August 2023

Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry

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