Drug Hunter

MAY 31, 2023

This article compiles 20+ recent small molecules of general interest in the news in April 2023, with structures where they are available.

Small Molecule 196

Small Molecule Clinical Trials Trials Drugs 196

Chemical Biology and Drug Design

JUNE 7, 2023

This article utilized template-based molecular docking of peptides and receptors to identify six highly valuable mutation sites. Subsequent amino acid multi-site mutations were conducted to establish a virtual polypeptide library.

Treatment 177

Treatment Research 177

Science Daily: Pharmacology News

NOVEMBER 13, 2024

A new article tackles these questions. How much land, water, and other resources does our lifestyle require? And how can we adapt this lifestyle to stay within the limits of what the Earth can give?

129

129

Drug Hunter

SEPTEMBER 17, 2023

We’ll have more detailed case studies on these molecules coming soon, but in the meantime you can check out some recent articles about the following here: VX-548 – oral NaV1.8 III clinical trials such as Vertex’s sodium channel inhibitor for acute pain and Denali Therapeutics’ CNS-penetrant eIF2B activator for ALS.

Clinical Trials 206

Clinical Trials Trials Therapies Pharmaceuticals 206

Drug Hunter

AUGUST 9, 2023

We’ll have more detailed case studies on these molecules coming soon, but in the meantime you can check out some recent articles about the following here: omaveloxolone – oral Nrf2 activator approved to treat Friedreich’s ataxia from modification of oleanoic acid (developed by Reata and acquired by Biogen). II P2X7R inhibitor.

Treatment 218

Treatment Drugs 218

Drug Hunter

MAY 21, 2023

This “journal club” article highlights five recent articles of general interest to drug discovery scientists, including reviews on therapeutic areas of interest, principles and areas of medicinal chemistry and pharmacology, and a synthetic transformation worth keeping in mind. A “Magic Chloro” Med. Chiodi and Y.

Trials 144

Trials Drugs 144

Chemical Biology and Drug Design

DECEMBER 9, 2024

This Expression of Concern is for the above article, published online on 12 February 2016, in Wiley Online Library ( [link] ), and has been issued by agreement between the journal Editor-in-Chief, Roberta Melander; and John Wiley & Sons Ltd. 1 (2016): 122-128, [link]. The authors disagree with the Expression of Concern.

Drugs 100

Drugs 100

Chemical Biology and Drug Design

DECEMBER 15, 2023

Given the substantial body of evidence supporting the neuroprotective potential of exendin-4 in various research models, this article is dedicated to exploring the promising role of exendin-4 as a therapeutic agent for the treatment and management of Alzheimer's disease and Parkinson's disease.

Disease 189

Disease Therapies Treatment Research 189

FDA Law Blog: Biosimilars

OCTOBER 16, 2023

Gonzalez — The Wall Street Journal (WSJ) recently published a series of articles as part of its special report “What’s Ahead for Artificial Intelligence.” Three of these articles focus on medical applications of Artificial Intelligence and Machine Learning (AI/ML) and explore FDA’s role in regulating such products.

Regulations 119

Regulations FDA Production Disease 119

Science Daily: Pharmacology News

NOVEMBER 4, 2024

This new study is described in the article as 'the first open-source and lightweight vision -- language foundation model, designed as a generalist capable of performing various biomedical tasks.' BiomedGPT is a new a new type of artificial intelligence (AI) designed to support a wide range of medical and scientific tasks.

125

125

Science Daily: Pharmacology News

JULY 1, 2024

This conclusion comes from researchers who reviewed over 300 scientific articles from many different fields of research. Human hunting, not climate change, played a decisive role in the extinction of large mammals over the last 50,000 years.

Research 122

Research 122

Science Daily: Pharmacology News

JULY 10, 2024

The most complete dinosaur discovered in the UK in the last 100 years, with a pubic hip bone the size of a 'dinner plate', has been described in a new article.

Research 120

Research 120

Science Daily: Pharmacology News

JULY 23, 2024

The insecticide-treated bed nets and insecticide sprays that were so effective in preventing mosquito bites -- and therefore malaria -- are increasingly viewed as the causes of household pest resurgence after pests became resistant to pesticides, according to a new article.

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121

Drug Hunter

MAY 21, 2023

This article highlights six recent articles of interest in the field of targeted protein degradation including but not limited to potentially new ligases, recruiting motifs, and a discussion on the feasibility of CNS-penetrant degraders.

Targeted Protein Degradation 131

Targeted Protein Degradation Trials Therapies Disease 131

Drug Hunter

JULY 21, 2023

Other notable Molecules of the Month include vorasidenib, which demonstrated headline-generating efficacy in brain cancers, as well as controversial billion-dollar molecule atrasentan, the subject of a short-seller report by Muddy Waters.

Structure Based Drug Design (SBDD) 227

Structure Based Drug Design (SBDD) Targeted Protein Degradation Clinical Trials Trials 227

Science Daily: Pharmacology News

JUNE 27, 2024

A new article shows how specific physical conditions -- especially ocean viscosity and resource deprivation -- during the global glaciation period known as Snowball Earth could have driven eukaryotes to turn multicellular.

121

121

Science Daily: Pharmacology News

JULY 29, 2024

Now, an interdisciplinary team of scientists has produced a perspective article of this co-evolutionary history. The atmosphere, the ocean and life on Earth interacted over the past 500-plus million years in ways that improved conditions for early organisms to thrive.

117

117

Science Daily: Pharmacology News

JUNE 25, 2024

A review article of the available studies directly comparing the impact of plant-based and animal-based meats consistently suggests that the plant-based alternatives improve cardiovascular risk factors.

117

117

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

The SAGA Survey just published three new research articles that provide us with new insights into the uniqueness of our own Milky Way Galaxy after completing the census of 101 satellite systems similar to the Milky Way's.

Research 113

Research 113

Drug Patent Watch

JANUARY 16, 2024

A recent article published in the Journal of Cheminformatics addresses the challenge of confirming the patent status of newly developed compounds, particularly in the pharmaceutical industry, where generating novel structures… The post An AI Approach to Generate Novel Pharmaceuticals using Patent Data appeared first on DrugPatentWatch - Make Better (..)

Pharmaceuticals 115

Pharmaceuticals 115

Drug Patent Watch

JANUARY 22, 2024

A recent article published in Health Affairs, delves into the Federal Trade Commission’s (FTC) concerns regarding the inclusion of improper patents in the FDA’s Orange Book by pharmaceutical manufacturers.

Pharmaceuticals 115

Pharmaceuticals 115

Drug Patent Watch

OCTOBER 16, 2024

This article delves into the impact of biosimilars on biologic drug… Source As patents for original biologic drugs expire, biosimilars are becoming increasingly important, offering more affordable treatment options for patients and healthcare systems.

Biosimilars 115

Biosimilars Drug Development Drugs Pharmaceuticals 115

KIF1A

FEBRUARY 10, 2024

Read the Article Rare Roundup Bespoke Gene Therapy Consortium Publishes First ‘Playbook’ to Bring Rare Disease Programs to Clinic Gene-based therapy is still a new arena; even as scientists across the world work on gene therapies, a major question is how to best prepare these treatments for clinical trials and regulatory approval.

Therapies 111

Therapies Clinical Trials FDA Disease 111

Drug Patent Watch

OCTOBER 10, 2024

This article will delve into the role of China in the global generic drug API market, exploring its market share… Source The country’s vast production capacity, low costs, and strategic location have made it an attractive destination for pharmaceutical companies seeking to source APIs.

Marketing 115

Marketing Pharmaceutical Companies Drugs Pharmaceuticals 115

Drug Patent Watch

JANUARY 8, 2024

The article “Settled: Patent characteristics and litigation outcomes in the pharmaceutical industry,” explores the relationship between Paragraph IV litigation characteristics and the probability of a Paragraph IV settlement in the… The post Unveiling the Secrets of Patent Litigation and Settlements in Pharmaceuticals appeared first on DrugPatentWatch (..)

Pharmaceuticals 111

Pharmaceuticals 111

Drug Patent Watch

JANUARY 9, 2024

The NPR article discusses the challenges in… The post NPR on how low Drug Prices can Shortages appeared first on DrugPatentWatch - Make Better Decisions. A recent story by NPR echoes the findings of a collaboration between DrugPatentWatch and Bloomberg, which examined increasing competition between generic drug makers.

Drugs 110

Drugs 110

Drug Patent Watch

JUNE 20, 2024

This article delves into the nuances of this process, shedding […] Source In the high-stakes world of pharmaceuticals, patents play a pivotal role in safeguarding intellectual property and ensuring a return on investment for drug developers.

Drugs 111

Drugs Drug Development Pharmaceuticals 111

Drug Patent Watch

JUNE 17, 2024

The article “The devil is in the divisional: an analysis of divisional patents, deadlines, declarations and suggestions for future practice” by Mieke Filler provides a comprehensive analysis of the strategic use of divisional patents in the pharmaceutical sector to delay generic and biosimilar market entry.

Biosimilars 110

Biosimilars Pharmaceuticals Marketing 110

Drug Hunter

JUNE 26, 2023

This article compiles recent high-profile clinical readouts and related news with small molecules of general interest and structures where they are available.

Small Molecule 130

Small Molecule RNA Trials Treatment 130

Drug Patent Watch

OCTOBER 14, 2024

This article will delve… Source The Food and Drug Administration (FDA) and other regulatory bodies have implemented various measures to ensure that generic drugs are equivalent to their brand-name counterparts in terms of quality, safety, and efficacy.

Drug Development 111

Drug Development Drugs FDA Production 111

Drug Patent Watch

MARCH 22, 2024

A recent article in Communications of the ACM explores opportunities for “Permissionless innovation” in pharmaceuticals. Permissionless innovation” refers to the freedom to explore new technologies or businesses without needing prior… Source

Pharmaceuticals 104

Pharmaceuticals 104

NIOSH Science Blog: Drugs

JUNE 5, 2024

Please download and share the free safety materials from NSC including a poster, social media kit, animated graphics, 5-minute safety talks, games, articles and more – plus NSC members get additional exclusive resources.

Research 117

Research 117

KIF1A

MARCH 16, 2024

In this week’s article, researchers in London reported on Whole Genome Sequencing results for 1515 patients with CMT and related disorders, finding a genetic diagnosis in 76.9% Read the Article The post ScienceSaturday: March 16, 2024 appeared first on KIF1A.

Disease 105

Disease Clinical Development Research Treatment 105

Science Daily: Pharmacology News

DECEMBER 20, 2023

But a new study by a team of researchers shows the opposite occurs: Searching to evaluate the truthfulness of false news articles actually increases the probability of believing misinformation. Conventional wisdom suggests that searching online to evaluate the veracity of misinformation would reduce belief in it.

Research 115

Research 115

Drug Patent Watch

OCTOBER 15, 2024

In this article, we’ll dive deep into this pharmaceutical conundrum… Source You’re not alone. Many people are puzzled by the discrepancy between a 92-day supply of pills and the actual number of days in a three-month period.

Pharmacy 110

Pharmacy Pharmaceuticals 110

Drug Patent Watch

SEPTEMBER 26, 2024

This article will discuss the key strategies and… Source Conducting an effective market analysis is crucial for pharmaceutical companies, policymakers, and healthcare professionals to understand the market dynamics and make informed decisions.

Marketing 105

Marketing Pharmaceutical Companies Drugs Pharmaceuticals 105

Drug Patent Watch

OCTOBER 7, 2024

This article delves into the importance of pharmacokinetics in generic drugs, addressing key aspects such as… Source PK studies help ensure that generic drugs are bioequivalent to their brand-name counterparts, meaning they have similar absorption, distribution, metabolism, and excretion (ADME) profiles.

Pharmacokinetics 105

Pharmacokinetics Drugs 105