Chemical Biology and Drug Design

FEBRUARY 3, 2025

The invitro biochemical assays validated that J1-65 inhibits PTP-PEST activity competitively and the inhibitor binding stabilizes the protein-ligand complex. An in-house molecule library was screened using in silico molecular docking, and a myo-inositol derivative was identified as a potent hit molecule.

Small Molecule 100

Small Molecule Biochemical Assays Regulations Drugs 100

Chemical Biology and Drug Design

MAY 17, 2024

Using fungal tyrosinase-based in vitro biochemical assay, we obtained one compound ( 3k ) which could inhibit tyrosinase activity, and the other compound ( 4f ) that stimulated tyrosinase activity. In the present study, we investigated these compounds for their potential as antagonists or agonists of tyrosinase.

Biochemical Assays 100

Biochemical Assays Regulations Production Research 100

Chemical Biology and Drug Design

JANUARY 23, 2024

Then, cardiac function parameters were assessed using echocardiography, myocardial injury markers were quantified via biochemical assays, and myocardial histopathological injuries were observed through H&E staining.

Biochemical Assays 100

Biochemical Assays Protein Expression Drugs Research 100

Molecular Design

JULY 18, 2020

The binding mode observed for 1 is shown below in Figure 1 and it’s likely that the groove region will need to be more fully exploited (this article will give you an idea of the sort of thing I have in mind) in order to achieve acceptable potency if the aldehyde warhead is replaced by nitrile. by forming a ring). by forming a ring).

Biochemical Assays 52

Biochemical Assays Fragment Screening Pharmacokinetics Drugs 52

Molecular Design

SEPTEMBER 18, 2024

In the Compatibility Issues section the authors state: Looking beyond laboratory-to-laboratory variability of assays that are nominally the same, there are numerous reasons why literature results for different assays measured against the same “target” may not be comparable.

Biochemical Assays 68

Biochemical Assays Drugs Biophysical Assays Cell Based Assays 68

Molecular Design

DECEMBER 19, 2023

I’ll be taking a look at H2023 (Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes) in this post and this article has also been discussed In The Pipeline. Carefully designed biochemical assays used in determining IC50 values can be well-suited as surrogates for k.inact/K.i measurements. (

Small Molecule 65

Small Molecule Biochemical Assays Cell Based Assays Drugs 65

Agency IQ

APRIL 12, 2024

Assays are tests designed to assess various properties (like potency) of chemical or biological samples.

Production 40

Production FDA Therapies Biochemical Assays 40