Chemical Biology and Drug Design

MAY 17, 2024

Using fungal tyrosinase-based in vitro biochemical assay, we obtained one compound ( 3k ) which could inhibit tyrosinase activity, and the other compound ( 4f ) that stimulated tyrosinase activity. In the present study, we investigated these compounds for their potential as antagonists or agonists of tyrosinase.

Biochemical Assays 100

Biochemical Assays Regulations Production Research 100

Chemical Biology and Drug Design

JANUARY 23, 2024

Then, cardiac function parameters were assessed using echocardiography, myocardial injury markers were quantified via biochemical assays, and myocardial histopathological injuries were observed through H&E staining.

Biochemical Assays 100

Biochemical Assays Protein Expression Drugs Research 100

Molecular Design

SEPTEMBER 18, 2024

In the Compatibility Issues section the authors state: Looking beyond laboratory-to-laboratory variability of assays that are nominally the same, there are numerous reasons why literature results for different assays measured against the same “target” may not be comparable.

Biochemical Assays 69

Biochemical Assays Biophysical Assays Drugs Cell Based Assays 69

Molecular Design

JULY 18, 2020

The binding mode observed for 1 is shown below in Figure 1 and it’s likely that the groove region will need to be more fully exploited (this article will give you an idea of the sort of thing I have in mind) in order to achieve acceptable potency if the aldehyde warhead is replaced by nitrile. by forming a ring). by forming a ring).

Biochemical Assays 52

Biochemical Assays Fragment Screening Pharmacokinetics Drugs 52

Molecular Design

DECEMBER 19, 2023

I’ll be taking a look at H2023 (Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes) in this post and this article has also been discussed In The Pipeline. Carefully designed biochemical assays used in determining IC50 values can be well-suited as surrogates for k.inact/K.i measurements. (

Small Molecule 66

Small Molecule Biochemical Assays Cell Based Assays Drugs 66

Agency IQ

APRIL 12, 2024

Assays are tests designed to assess various properties (like potency) of chemical or biological samples.

Production 40

Production FDA Therapies Biochemical Assays 40

Molecular Design

DECEMBER 6, 2023

I’ll be taking a look at B2023 (Fused Tetrahydroquinolines Are Interfering with Your Assay) in this post. The article has already been discussed in posts at Practical Fragments and In The Pipeline. It’s also worth noting that interference with read-out can also lead to false negatives.

Biochemical Assays 53

Biochemical Assays Small Molecule Laboratories Drugs 53