Chemical Biology and Drug Design

FEBRUARY 3, 2025

The invitro biochemical assays validated that J1-65 inhibits PTP-PEST activity competitively and the inhibitor binding stabilizes the protein-ligand complex. PTP-PEST is considered an important drug target owing to its involvement in cancer progression and myocardial injury.

Small Molecule 100

Small Molecule Biochemical Assays Regulations Drugs 100

Chemical Biology and Drug Design

JANUARY 23, 2024

Betulinic acid (BA) improved cardiac function, reduced myocardial injury, and attenuated inflammation in the cecal ligation and puncture (CLP) rats, indicating BA as a potential drug for sepsis-induced myocardial dysfunction.

Biochemical Assays 100

Biochemical Assays Protein Expression Drugs Research 100

Molecular Design

SEPTEMBER 18, 2024

In the Compatibility Issues section the authors state: Looking beyond laboratory-to-laboratory variability of assays that are nominally the same, there are numerous reasons why literature results for different assays measured against the same “target” may not be comparable.

Biochemical Assays 68

Biochemical Assays Biophysical Assays Drugs Cell Based Assays 68

Molecular Design

JULY 18, 2020

Satchel Paige (1906-1982) The COVID Moonshot and OSC19 are examples of what are sometimes called crowdsourced or open source approaches to drug discovery. Open source drug discovery originated with OSDD in India and it should be noted that the approach has also been pioneered for malaria by OSM.

Biochemical Assays 52

Biochemical Assays Fragment Screening Pharmacokinetics Drugs 52

Molecular Design

DECEMBER 19, 2023

I’ll be taking a look at H2023 (Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes) in this post and this article has also been discussed In The Pipeline. This Perspective is intended to jumpstart this important scientific discussion. Subscripting doesn't work well in blogger and so I'll use K.i

Small Molecule 65

Small Molecule Biochemical Assays Cell Based Assays Drugs 65

Drug Target Review

JANUARY 5, 2024

fowleri cases 3 suggest that combinations of antibiotic and antifungal drugs, including azithromycin, amphotericin B, fluconazole, rifampin and miltefosine (the latter originally formulated for leishmaniasis and cancer chemotherapy 4 ), have a minimal impact on survival. The activity of Z#1334 in inhibiting Nf Ga7 GTPase assay (IC 50 of 2.4

Small Molecule 59

Small Molecule Drugs Biochemical Assays Regulations 59

Agency IQ

APRIL 12, 2024

Assays are tests designed to assess various properties (like potency) of chemical or biological samples. In addition to assessing binding capabilities, assays can also be used to characterize the activity elicited by a product, whether bound or unbound to the target of interest. Code in order to have their products approved by the FDA.

Production 40

Production FDA Therapies Biochemical Assays 40