Chemical Biology and Drug Design

JULY 4, 2023

Acacetin, as a natural flavonoid drug, modulates the activity of JAK2/STAT3 pathway, to suppress the growth, migration, invasion and anti-apoptosis of cancer cells and block the progression of esophageal cancer. Acacetin may be a promising drug in complementary therapy of cancer treatment.

Bioinformatics 100

Bioinformatics Regulations Treatment Therapies 100

Chemical Biology and Drug Design

JULY 13, 2023

Bioinformatics analysis was performed to predict the molecular targets of COP. In summary, COP represses the malignant biological behaviors of bladder carcinoma cells and regulates XPO1 expression, which is promising to be a complementary drug for bladder carcinoma treatment.

Regulations 100

Regulations Bioinformatics Treatment Drugs 100

Chemical Biology and Drug Design

DECEMBER 28, 2023

In present study, LINC00460 was screened out through bioinformatics analysis. Silencing of LINC00460 increased drug sensitivity and induced apoptosis in DDP-resistant-cervical cancer cells. The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer.

Bioinformatics 100

Bioinformatics RNA Regulations Drugs 100

Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p expression in LUAD and the target gene downstream of hsa-miR-503-5p was predicted by bioinformatics analysis. Abstract The study aimed to assess the role of hsa-miR-503-5p in cisplatin resistance and angiogenesis in LUAD and its underlying mechanisms. Hsa-miR-503-5p also had high expression in cisplatin-resistant LUAD cells.

Regulations 100

Regulations Protein Expression Bioinformatics Drugs 100

Chemical Biology and Drug Design

MARCH 14, 2023

EVO regulates ovarian cancer progression through the NEAT1-miR-152-3p-CDK19 axis, which further advances the possibility of EVO as a therapeutic drug for ovarian cancer. Abstract Evodiamine (EVO) has been demonstrated to promote apoptosis of ovarian cancer cells, and upregulate miR-152-3p level in colorectal cancer.

Regulations 100

Regulations Bioinformatics Drugs Research 100

Drug Target Review

MAY 24, 2024

More explanation and practical tips for using these technologies will be explored in future articles. According to a prominent article ten years back, 4 data scientists spend up to 80 percent of their time mired in the mundane labour of collecting and preparing unruly digital data, before it can be explored for useful nuggets.

RNA 59

RNA DNA Bioinformatics Science 59

Dark Matter Blog

AUGUST 31, 2020

The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. To this end, we selected a known rSM-RNA system, Aptamer 21, which possessed several attractive features.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Vial

DECEMBER 5, 2023

It has become a fundamental tool for researchers to explore the complexities of genetic information and conduct genetic-informed drug development. Among others, NGS has led to the identification of disease-causing variants and novel drug targets and an improved understanding of complex biological events, e.g., the heterogeneity of tumors.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

The Open Targets Blog

APRIL 19, 2022

For example, exploring the most similar drugs for Cutaneous Melanoma using the Bibliography widget on its profile page in the Open Targets Platform brings up a list of top terms. Thanks to the latest developments in the field of NLP, we can much better identify targets, diseases, and drugs occurring in the literature.

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Disease Bioinformatics FDA Production 52

DrugBank

MARCH 15, 2023

In addition to our talented medical experts, who work tirelessly to ensure that our drug knowledgebase is the most accurate, up-to-date, and usable on the market, we have a versatile customer team that is singularly focused on making your work with us as easy and effective as possible. We also host product demonstrations.

Licensing 52

Licensing Licensing International Bioinformatics 52

Chemical Biology and Drug Design

NOVEMBER 27, 2023

The expression and activity of AchE is changed in tumors, suggesting AChE inhibitors (AchEIs) may serve as potential antitumor drugs. Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ.

Bioinformatics 100

Bioinformatics RNA Regulations Therapies 100

Agency IQ

OCTOBER 12, 2023

Leaders at FDA share highlights and updates for drugs and biologics at RAPS Convergence Top officials from FDA’s Centers for drugs and biologics—including Center for Biologics Evaluation and Research (CBER) Director Peter Marks—provided high-level updates at RAPS Convergence 2023 this week.

FDA 40

FDA Clinical Trials International Drugs 40

Drug Target Review

DECEMBER 28, 2023

Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Using powerful bioinformatics technology developed and validated with sequence data from the TRACERx study, researchers are able to identify clonal neoantigens from a patient’s unique tumour profile.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

PLOS: DNA Science

MAY 16, 2024

Other genomic databases were retooled for the huge datasets that COVID was generating, such as the Cloud Institute for Microbial Bioinformatics, begun in 2014 and rechristened the COVID-19 Genomics UK Consortium ( COG-UK ). And so variants alpha, delta, omicron emerged,” write the authors of the Frontiers in Science paper.

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Virus DNA RNA Vaccine 98

Drug Target Review

APRIL 11, 2025

Drug development is hampered by high costs, long timelines and a low probability of success and complex therapies exacerbate these challenges. This promises to significantly improve the probability of success for new drugs, accelerating their development and ultimately delivering life-saving treatments to patients faster.

Clinical Development 76

Clinical Development Drugs Pharmaceuticals Clinical Trials 76

Chemical Biology and Drug Design

MARCH 4, 2025

Network pharmacology and bioinformatics analysis showed that the role of FA in treating IS was associated with oxidative stress. In conclusion, FA attenuates the oxidative damage induced by IS by activating the Nrf2/HO-1 signaling pathway, which is a promising natural drug for IS.

Bioinformatics 100

Bioinformatics Treatment Drugs Research 100

Codon

APRIL 16, 2023

BMC Bioinformatics. Read There’s a news article that breaks down this work. Read Local generation and efficient evaluation of numerous drug combinations in a single sample. Read Retracted Covid-19 articles: significantly more cited than other articles within their journal of origin. McCafferty C.L.

Engineering 52

Engineering DNA RNA Science 52

Drug Target Review

MARCH 13, 2025

Planning the journey from data to deliverables The future of AI-enabled drug development benefits from the continued advancement of multimodality and clinical genomics, with a focus on integration, efficiency and personalisation to transform both care and R&D.

Drug Development 59

Drug Development Science Clinical Trials FDA 59

Codon

AUGUST 28, 2024

This article concludes our mini-issue. 5 But it could match up to one of the threats in your reference database, so you opt to throw a battery of bioinformatics tools at it. BLAST is covered in every introductory bioinformatics course and the 1990 paper introducing has over 110,000 citations. Bioinformatic results from HMMScan.

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DNA Bioinformatics Virus Government 92

Drug Target Review

FEBRUARY 11, 2025

Drug development: addressing complexity and success rates Drug development is a complex and expensive process, requiring multidisciplinary expertise and high-risk financial investments. The financial burden of drug development is substantial, often exceeding $2 billion per drug. Unfortunately, many drug candidates fail.

Drug Development 59

Drug Development Bioinformatics Drugs Small Molecule 59