Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p expression in LUAD and the target gene downstream of hsa-miR-503-5p was predicted by bioinformatics analysis. The results showed that hsa-miR-503-5p showed high expression, while its target gene CTDSPL presented decreased expression in LUAD.

Regulations 100

Regulations Protein Expression Bioinformatics Drugs 100

Chemical Biology and Drug Design

AUGUST 20, 2023

Hederagenin attenuated HG-induced increase in mRNA and protein expression of NLRP3, ASC, and IL-1β. Bioinformatics analysis predicted cathepsin B (CTSB) as a target of hederagenin to modulate NOD-like receptor (NLR) pathway. Hederagenin also suppressed HG-induced increase in mRNA and secretion levels of FN, Col.

Bioinformatics 100

Bioinformatics Protein Expression Research 100

Chemical Biology and Drug Design

AUGUST 9, 2023

A label-free proteomics technology was employed to investigate alterations in protein expression in LoVo cells treated with plumbagin. The LC-MS/MS proteomics assay revealed 78 proteins that were differentially expressed upon treatment with plumbagin.

Bioinformatics 100

Bioinformatics Protein Expression Treatment Research 100