Article, Bioinformatics and Regulations

Article

Bioinformatics

Regulations

Screening and introduction of key cell cycle microRNAs deregulated in colorectal cancer by integrated bioinformatics analysis

Chemical Biology and Drug Design

APRIL 20, 2023

Impaired cell cycle regulation leads to many cancers and is also approved in CRC. Therefore, cell cycle regulation is a critical therapeutic target for CRC. Furthermore, miRNAs have been discovered as regulators in a variety of cancer-related pathways.

Bioinformatics

Bioinformatics Regulations Drugs Research

Coptisine inhibits the malignancy of bladder carcinoma cells and regulates XPO1 expression

Chemical Biology and Drug Design

JULY 13, 2023

Coptisine inhibits the malignancy of BC cells via regulating XPO1. Bioinformatics analysis was performed to predict the molecular targets of COP. Abstract This work is performed to investigate the effect of coptisine (COP) on the malignant biological behaviors of bladder carcinoma cells and its underlying mechanism.

Regulations

Regulations Bioinformatics Treatment Drugs

Join 15,000+

Insiders

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

Chemical Biology and Drug Design

Hsa?miR?503?5p regulates CTDSPL to accelerate cisplatin resistance and angiogenesis of lung adenocarcinoma cells

Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p negatively regulates CTDSPL, suggesting its potential as a target to overcome cisplatin resistance in LUAD. Hsa-miR-503-5p expression in LUAD and the target gene downstream of hsa-miR-503-5p was predicted by bioinformatics analysis.

Regulations

Regulations Protein Expression Bioinformatics Drugs

Evodiamine inhibits malignant progression of ovarian cancer cells by regulating lncRNA?NEAT1/miR?152?3p/CDK19 axis

Chemical Biology and Drug Design

MARCH 14, 2023

EVO regulates ovarian cancer progression through the NEAT1-miR-152-3p-CDK19 axis, which further advances the possibility of EVO as a therapeutic drug for ovarian cancer. EVO dose-dependently attenuated cell viability, induced G2/M phase arrest, and apoptosis in ovarian cancer cells.

Regulations

Regulations Bioinformatics Drugs Research

The first major set of genetic associations found in long COVID

Drug Target Review

DECEMBER 13, 2023

The study mentions the overlap in genes associated with Fatigue Dominant long COVID and ME/CFS, including those involved in circadian rhythm regulation and insulin regulation. The article mentions that TLR4 antagonists have been identified as potential candidates for repurposing long COVID treatment.

Bioinformatics

Bioinformatics Disease Regulations Immune Response

Acacetin restrains the malignancy of esophageal squamous carcinoma cells via regulating JAK2/STAT3 pathway

Chemical Biology and Drug Design

JULY 4, 2023

Genes related to acacetin and esophageal cancer were predicted by bioinformatics analysis. In this work, esophageal squamous carcinoma cell lines were subjected to increasing doses of acacetin, and the proliferative, migrative, invasive and apoptotic phenotypes were evaluated by a series of in vitro experiments.

Bioinformatics

Bioinformatics Regulations Treatment Therapies

IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820?encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer

Chemical Biology and Drug Design

FEBRUARY 20, 2024

Moreover, bioinformatics analysis has suggested that hsa_circRNA_103820 possesses potential peptide-coding ability. IGF2BP3 negatively regulated hsa_circRNA_103820 expression and interacted with it. Hsa_circRNA_103820 is implicated in the pathogenesis of multiple cancers, including lung cancer (LC).

Bioinformatics

Bioinformatics RNA Regulations Research

Stachydrine represses the proliferation and enhances cell cycle arrest and apoptosis of breast cancer cells via PLA2G2A/DCN axis

Chemical Biology and Drug Design

JANUARY 1, 2024

Then, Bioinformatics was applied to sort out the candidate interacting with Stachydrine as well as its expression and downstream target in BC. Abstract Considering the therapeutic efficacy of Stachydrine on breast cancer (BC), this study aims to decipher the relevant mechanism.

Bioinformatics

Bioinformatics Regulations Disease Research

LINC00460 knockdown sensitizes cervical cancer to cisplatin by downregulating TGFBI

Chemical Biology and Drug Design

DECEMBER 28, 2023

LINC00460 knockdown contributed to DDP sensitivity of cervical cancer by regulating TGFBI, providing a novel mechanism underlying the acquisition of DDP sensitivity. In present study, LINC00460 was screened out through bioinformatics analysis. However, its effect on DDP sensitivity in cervical cancer remains poorly understood.

Bioinformatics

Bioinformatics RNA Regulations Drugs

Identification of a 2?phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells

Chemical Biology and Drug Design

NOVEMBER 27, 2023

A6 play anticancer role by regulating Best1 and HIST1H2BJ. Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ. A6 significantly disrupted the amino acid metabolism, inhibited migration and invasion and induced apoptosis of MCF-7.

Bioinformatics

Bioinformatics RNA Regulations Therapies

Next Generation Sequencing (NGS) in Clinical Trials: Challenges and Opportunities

Vial

DECEMBER 5, 2023

The application of NGS has given researchers deep insights into genetic variation, gene expression, epigenetic modifications, alternative splicing, non-coding RNA regulation, microbial diversity, and various biological processes and diseases. In addition, NGS facilitates transcriptomics , epigenomics, metagenomics, and other omics studies.

Clinical Trials

Clinical Trials Trials RNA Bioinformatics

Is That DNA Dangerous?

Codon

AUGUST 28, 2024

This article concludes our mini-issue. One way to detect toxin-coding genes is to store the genomes of regulated pathogens and any genes that encode regulated toxins in a new database. Also, such screening must take into account that many regulated toxins have beneficial applications. Thanks for reading! For now, the U.S.

DNA

DNA Bioinformatics Virus Government

Codon Digest: GPT-4 Controls a Robot

Codon

APRIL 16, 2023

Read Deep learning of genomic contexts predicts protein co-regulation and function. BMC Bioinformatics. Read There’s a news article that breaks down this work. Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Read ICOR: improving codon optimization with recurrent neural networks.

Engineering

Engineering DNA RNA Science

Drug Discovery Digest

Screening and introduction of key cell cycle microRNAs deregulated in colorectal cancer by integrated bioinformatics analysis

Coptisine inhibits the malignancy of bladder carcinoma cells and regulates XPO1 expression

Trending Sources

Hsa?miR?503?5p regulates CTDSPL to accelerate cisplatin resistance and angiogenesis of lung adenocarcinoma cells

Evodiamine inhibits malignant progression of ovarian cancer cells by regulating lncRNA?NEAT1/miR?152?3p/CDK19 axis

The first major set of genetic associations found in long COVID

Acacetin restrains the malignancy of esophageal squamous carcinoma cells via regulating JAK2/STAT3 pathway

IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820?encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer

Stachydrine represses the proliferation and enhances cell cycle arrest and apoptosis of breast cancer cells via PLA2G2A/DCN axis

LINC00460 knockdown sensitizes cervical cancer to cisplatin by downregulating TGFBI

Identification of a 2?phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells

Next Generation Sequencing (NGS) in Clinical Trials: Challenges and Opportunities

Is That DNA Dangerous?

Codon Digest: GPT-4 Controls a Robot

Stay Connected