Elrig

MARCH 25, 2025

Prof Rory Johnson is an Associate Professor at University College Dublin, where his research focusses on uncovering the roles of long noncoding RNAs (lncRNAs) in human health and disease using an interdisciplinary combination of bioinformatic and experimental methods.

RNA 59

RNA Bioinformatics Science Pharmacokinetics 59

Chemical Biology and Drug Design

NOVEMBER 27, 2023

A6 play anticancer role by regulating Best1 and HIST1H2BJ. Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ. A6 significantly disrupted the amino acid metabolism, inhibited migration and invasion and induced apoptosis of MCF-7.

Bioinformatics 100

Bioinformatics RNA Regulations Therapies 100

Chemical Biology and Drug Design

JANUARY 1, 2024

Then, Bioinformatics was applied to sort out the candidate interacting with Stachydrine as well as its expression and downstream target in BC. Abstract Considering the therapeutic efficacy of Stachydrine on breast cancer (BC), this study aims to decipher the relevant mechanism.

Bioinformatics 100

Bioinformatics Regulations Disease Research 100

Chemical Biology and Drug Design

DECEMBER 28, 2023

LINC00460 knockdown contributed to DDP sensitivity of cervical cancer by regulating TGFBI, providing a novel mechanism underlying the acquisition of DDP sensitivity. In present study, LINC00460 was screened out through bioinformatics analysis. However, its effect on DDP sensitivity in cervical cancer remains poorly understood.

Bioinformatics 100

Bioinformatics RNA Regulations Drugs 100

Vial

DECEMBER 5, 2023

The application of NGS has given researchers deep insights into genetic variation, gene expression, epigenetic modifications, alternative splicing, non-coding RNA regulation, microbial diversity, and various biological processes and diseases. In addition, NGS facilitates transcriptomics , epigenomics, metagenomics, and other omics studies.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

Codon

AUGUST 28, 2024

This article concludes our mini-issue. One way to detect toxin-coding genes is to store the genomes of regulated pathogens and any genes that encode regulated toxins in a new database. Also, such screening must take into account that many regulated toxins have beneficial applications. Thanks for reading! For now, the U.S.

DNA 95

DNA Bioinformatics Virus Government 95

Chemical Biology and Drug Design

FEBRUARY 5, 2025

Differentially expressed genes (DEGs) involved in luteolin and quercetin action that regulate adipogenic differentiation were identified using RNA sequencing (RNA-seq). Bioinformatic analyses were performed to identify potential target genes and pathways regulated by luteolin/quercetin during adipogenesis.

RNA 100

RNA Bioinformatics Regulations Research 100

Drug Target Review

MARCH 13, 2025

The journey from distrust to collaboration among industry, academia and regulators will expedite integration, minimise clinical failures and enhance economic sustainability. This article, along with other insightful analyses, will be featured in our upcoming report, Beyond the Lab – Artificial Intelligence, launching on 21st March 2025.

Drug Development 59

Drug Development Science Clinical Trials FDA 59

Codon

APRIL 16, 2023

Read Deep learning of genomic contexts predicts protein co-regulation and function. BMC Bioinformatics. Read There’s a news article that breaks down this work. Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Read ICOR: improving codon optimization with recurrent neural networks.

Engineering 52

Engineering DNA RNA Science 52