Drug Target Review

DECEMBER 28, 2023

Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Using powerful bioinformatics technology developed and validated with sequence data from the TRACERx study, researchers are able to identify clonal neoantigens from a patient’s unique tumour profile.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Chemical Biology and Drug Design

JUNE 11, 2024

Therefore, our research revealed the biological effect of brusatol treatment and provided ATF3 as a novel therapeutic target and prognostic biomarker for HCC therapy. RNA sequencing (RNA-seq) and bioinformatics analyses of HCC cells were utilized to elucidate the mechanism underlying the effects of BRU in HCC.

RNA 100

RNA Bioinformatics Treatment Therapies 100

Chemical Biology and Drug Design

MARCH 28, 2023

Pharmacodynamic targets of metformin were predicted using the Bioinformatics Analysis Tool for the molecular mechanism of traditional Chinese medicine (BATMAN), Drugbank, PharmMapper, SwissTargetPrediction, and TargetNet databases.

Bioinformatics 100

Bioinformatics Drugs Research 100

Chemical Biology and Drug Design

JULY 4, 2023

Genes related to acacetin and esophageal cancer were predicted by bioinformatics analysis. In this work, esophageal squamous carcinoma cell lines were subjected to increasing doses of acacetin, and the proliferative, migrative, invasive and apoptotic phenotypes were evaluated by a series of in vitro experiments.

Bioinformatics 100

Bioinformatics Regulations Treatment Therapies 100

Chemical Biology and Drug Design

JULY 13, 2023

Bioinformatics analysis was performed to predict the molecular targets of COP. Cell counting kit-8 (CCK-8), scratch healing assay, Transwell assay, and flow cytometry were used to detect cell growth, migration, invasion, and cell cycle progression.

Regulations 100

Regulations Bioinformatics Treatment Drugs 100

Chemical Biology and Drug Design

FEBRUARY 20, 2024

Moreover, bioinformatics analysis has suggested that hsa_circRNA_103820 possesses potential peptide-coding ability. Abstract N6-methyladenosine (m6A) modification and m6A-related RNA-binding proteins (RBPs) play vital roles in various aspects of circRNA metabolism.

Bioinformatics 100

Bioinformatics RNA Regulations Research 100

Chemical Biology and Drug Design

NOVEMBER 27, 2023

Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ. A total of 153 genes were increased, and the expression of 81 genes was decreased.

Bioinformatics 100

Bioinformatics RNA Regulations Therapies 100

Chemical Biology and Drug Design

JANUARY 5, 2024

Homeobox B7 (HOXB7) expression in CRC was analyzed and detected by bioinformatics analysis, quantitative real-time PCR or western blot. Following the treatment of 0, 1.94, 7.75, or 19.36 μM μM THA, CRC cell viability, apoptosis, migration, and invasion were evaluated by methyl tetrazolium, flow cytometry, wound-healing, and transwell assays.

Bioinformatics 100

Bioinformatics Cell Biology Treatment Research 100

Chemical Biology and Drug Design

AUGUST 20, 2023

Bioinformatics analysis predicted cathepsin B (CTSB) as a target of hederagenin to modulate NOD-like receptor (NLR) pathway. NLRP3 inhibitor MCC950 attenuated HG-induced fibrosis of renal cells, and its activator nigericin reversed the suppressive effect of hederagenin on HG-induced fibrosis.

Bioinformatics 100

Bioinformatics Protein Expression Research 100

Chemical Biology and Drug Design

JANUARY 1, 2024

Then, Bioinformatics was applied to sort out the candidate interacting with Stachydrine as well as its expression and downstream target in BC. Abstract Considering the therapeutic efficacy of Stachydrine on breast cancer (BC), this study aims to decipher the relevant mechanism.

Bioinformatics 100

Bioinformatics Regulations Disease Research 100

Chemical Biology and Drug Design

DECEMBER 28, 2023

In present study, LINC00460 was screened out through bioinformatics analysis. The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer. However, its effect on DDP sensitivity in cervical cancer remains poorly understood. The sensitivity to DDP was investigated using an CCK8 assay.

Bioinformatics 100

Bioinformatics RNA Regulations Drugs 100

Chemical Biology and Drug Design

AUGUST 9, 2023

Bioinformatics and functional analyses indicated that these proteins were predominantly involved in protein synthesis and translation. Our investigation indicated that plumbagin markedly inhibited the LoVo cells proliferation, and induced the apoptosis in LoVo cells, simultaneously induced G0/G1 phase cell cycle arrest.

Bioinformatics 100

Bioinformatics Protein Expression Treatment Research 100

Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p expression in LUAD and the target gene downstream of hsa-miR-503-5p was predicted by bioinformatics analysis. Abstract The study aimed to assess the role of hsa-miR-503-5p in cisplatin resistance and angiogenesis in LUAD and its underlying mechanisms.

Regulations 100

Regulations Protein Expression Bioinformatics Drugs 100

Chemical Biology and Drug Design

MARCH 14, 2023

The bioinformatics website, dual luciferase reporter assay, and quantitative real-time polymerase chain reaction were applied to analyze the network among EVO, lncRNA, miR-152-3p, and mRNA. Abstract Evodiamine (EVO) has been demonstrated to promote apoptosis of ovarian cancer cells, and upregulate miR-152-3p level in colorectal cancer.

Regulations 100

Regulations Bioinformatics Drugs Research 100

Chemical Biology and Drug Design

FEBRUARY 7, 2024

We assessed the effect of HSYA and NF-κB signaling pathway-related genes by bioinformatics analysis and conducted molecular docking to assess the interaction of HSYA with a combined protein residue molecule ligand. Western blot was employed to investigate NF-κB transcription factors in chondrocyte metabolism.

Bioinformatics 100

Bioinformatics Treatment Production Disease 100

Drug Target Review

MAY 24, 2024

More explanation and practical tips for using these technologies will be explored in future articles. According to a prominent article ten years back, 4 data scientists spend up to 80 percent of their time mired in the mundane labour of collecting and preparing unruly digital data, before it can be explored for useful nuggets.

RNA 59

RNA DNA Bioinformatics Science 59

The Pharma Data

JANUARY 24, 2021

His research focuses on the role of the microbiome in immune defense and disease resistance. “We He has published more than 200 articles and book chapters. Diversigen provides consultative end-to-end solutions for sequencing, bioinformatics, and statistical analysis for the study of the microbiome of living organisms and environments.

Research 40

Research Bioinformatics Laboratories International 40

Agency IQ

OCTOBER 12, 2023

Leaders at FDA share highlights and updates for drugs and biologics at RAPS Convergence Top officials from FDA’s Centers for drugs and biologics—including Center for Biologics Evaluation and Research (CBER) Director Peter Marks—provided high-level updates at RAPS Convergence 2023 this week. Featuring previous research by Alec Gaffney.

FDA 40

FDA Clinical Trials International Drugs 40

Dark Matter Blog

AUGUST 31, 2020

However, since most small molecule drugs target proteins in the cell, the vast majority of target identification methods available to research scientists are aimed at identifying interactions between small molecules and proteins.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Vial

DECEMBER 5, 2023

Next-generation sequencing (NGS) has revolutionized scientific research and clinical genomics due to high-throughput multiplexing and shed light on genome structure, function, and dynamics. It has become a fundamental tool for researchers to explore the complexities of genetic information and conduct genetic-informed drug development.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

DrugBank

MARCH 15, 2023

Our relationship often starts with a tailored onboarding program intended to make incorporating DrugBank knowledge into their research or software faster and easier. We also author articles alongside Customer Success, research and write blogs , and host webinars. We also get to hear about their successes and what works well.

Licensing 52

Licensing Licensing International Bioinformatics 52

The Open Targets Blog

APRIL 19, 2022

How can we systematically query that knowledge to provide researchers with the most relevant information? The driving question behind this project – how can we systematically query the knowledge contained in the scientific literature to provide researchers with the most relevant information?

Disease 52

Disease Bioinformatics FDA Production 52

Codon

AUGUST 28, 2024

This article concludes our mini-issue. When the CDC contacted Harris to ask about the plague samples, Harris claimed that he was doing research for the CIA to stop an “imminent invasion from Iraq of super-germ-carrying rats.” Starting in October, researchers receiving funds from the U.S. Thanks for reading!

DNA 90

DNA Bioinformatics Virus Government 90

Chemical Biology and Drug Design

FEBRUARY 5, 2025

Bioinformatic analyses were performed to identify potential target genes and pathways regulated by luteolin/quercetin during adipogenesis. Differentially expressed genes (DEGs) involved in luteolin and quercetin action that regulate adipogenic differentiation were identified using RNA sequencing (RNA-seq).

RNA 100

RNA Bioinformatics Regulations Research 100

Chemical Biology and Drug Design

MARCH 4, 2025

Network pharmacology and bioinformatics analysis showed that the role of FA in treating IS was associated with oxidative stress. The Nrf2 inhibitor ML385 was used for the rescue experiments. Topological analysis of the PPI network revealed 11 key genes, which were closely associated with the Nrf2 pathway.

Bioinformatics 100

Bioinformatics Treatment Drugs Research 100

Drug Target Review

FEBRUARY 11, 2025

These hurdles not only delay patient access to innovative treatments but also threaten the economic sustainability of research and development (R&D) and the advancement of medical innovation. Furthermore, uneven access to genomic data amplifies inequalities in research.

Drug Development 59

Drug Development Bioinformatics Drugs Small Molecule 59

Drug Target Review

MARCH 13, 2025

Elnora AI exemplifies an innovative data augmentation strategy by collecting negative data directly from academic researchers, focusing on detailed lab protocols. This article, along with other insightful analyses, will be featured in our upcoming report, Beyond the Lab – Artificial Intelligence, launching on 21st March 2025.

Drug Development 59

Drug Development Clinical Trials Science FDA 59

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. AI + Bio *Emergent autonomous scientific research capabilities of large language models. BMC Bioinformatics. Read There’s a news article that breaks down this work. Please send me your feedback. Favate J.S.

Engineering 52

Engineering DNA RNA Science 52