Elrig

MARCH 25, 2025

This second ELRIG meeting on Therapeutic Oligonucleotides brings together esteemed scientists from academia, industry, and other members of the drug discovery community to explore the discovery, validation, and targeting of oligonucleotide-based drug candidates, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).

RNA 59

RNA Bioinformatics Science Pharmacokinetics 59

Chemical Biology and Drug Design

JUNE 11, 2024

Using RNA-seq and through in vitro and in vivo studies, we determined that brusatol suppresses hepatocellular carcinoma progression by inducing ATF3-mediated ferroptosis. RNA sequencing (RNA-seq) and bioinformatics analyses of HCC cells were utilized to elucidate the mechanism underlying the effects of BRU in HCC.

RNA 100

RNA Bioinformatics Treatment Therapies 100

Drug Target Review

DECEMBER 6, 2024

This article outlines the various stages of such a workflow, from hypothesis generation to data cleaning and interpretation, referencing the project workflow diagram (Figure 1). At the heart of any research is the scientific question.

RNA 52

RNA Drugs Research Science 52

Chemical Biology and Drug Design

DECEMBER 28, 2023

The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer. In present study, LINC00460 was screened out through bioinformatics analysis. Abstract The acquired resistance of cancer to cisplatin (DDP) limits the efficacy of chemotherapy.

Bioinformatics 100

Bioinformatics RNA Regulations Drugs 100

Dark Matter Blog

AUGUST 31, 2020

Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA. Today, we are pleased to announce that our article describing one such platform: “ PEARL-seq, A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions ” was published in ACS Chemical Biology.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Chemical Biology and Drug Design

FEBRUARY 20, 2024

Abstract N6-methyladenosine (m6A) modification and m6A-related RNA-binding proteins (RBPs) play vital roles in various aspects of circRNA metabolism. Moreover, bioinformatics analysis has suggested that hsa_circRNA_103820 possesses potential peptide-coding ability.

Bioinformatics 100

Bioinformatics RNA Regulations Research 100

Chemical Biology and Drug Design

NOVEMBER 27, 2023

To clarify how A6 affected on MCF-7 cells, RNA-seq analysis was conducted to evaluate the whole genome effect of A6 on gene expression. Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ. In addition, A6 induced apoptosis of MCF-7 cells.

Bioinformatics 100

Bioinformatics RNA Regulations Therapies 100