Practical Cheminformatics

JANUARY 16, 2024

Following up on Part I and Part II, the third post in this series is a collection of review articles published in 2023 that I found helpful.

Targeted Protein Degradation 139

Targeted Protein Degradation Small Molecule Computational Chemistry Bioinformatics 139

Dark Matter Blog

AUGUST 31, 2020

The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Drug Target Review

FEBRUARY 11, 2025

Drugs that were developed and commercialised 30+ years ago were relatively simple small molecules. Todays small molecules are far larger, more complex, and chase highly specific (and difficult to hit) targets, thereby increasing the chances of undesired side effects. This failure is getting more pronounced by the day.

Drug Development 59

Drug Development Bioinformatics Drugs Small Molecule 59

Codon

APRIL 16, 2023

BMC Bioinformatics. Read There’s a news article that breaks down this work. Read Retracted Covid-19 articles: significantly more cited than other articles within their journal of origin. Read Deep learning of genomic contexts predicts protein co-regulation and function. McCafferty C.L. Favate J.S. Debès C.

Engineering 52

Engineering DNA RNA Science 52