Article, Bioinformatics and Treatment

ANKRD22 promotes M2 polarization in lung adenocarcinoma macrophages via the glycolytic pathway

Chemical Biology and Drug Design

JANUARY 15, 2024

The expression of ANKRD22 in LUAD and its enriched pathway were analyzed by bioinformatics analysis. Bioinformatics analysis, qRT-PCR, and western blot showed that ANKRD22 was highly expressed in LUAD, which had a positive connection with M2 marker genes. Mitochondrial membrane potential was assessed using the JC-1 probe.

Bioinformatics

Bioinformatics Treatment Research

The first major set of genetic associations found in long COVID

Drug Target Review

DECEMBER 13, 2023

The article mentions that TLR4 antagonists have been identified as potential candidates for repurposing long COVID treatment. Type 2 diabetes-related signalling pathways and insulin resistance were also a key theme within the genes associated with long COVID. Can you elaborate on how these antagonists may help with long COVID?

Bioinformatics

Bioinformatics Disease Regulations Immune Response

Brusatol induces ferroptosis to inhibit hepatocellular carcinoma progression by targeting ATF3

Chemical Biology and Drug Design

JUNE 11, 2024

Therefore, our research revealed the biological effect of brusatol treatment and provided ATF3 as a novel therapeutic target and prognostic biomarker for HCC therapy. However, the exact mechanism of BRU in the treatment of hepatocellular carcinoma (HCC) remains unknown.

RNA

RNA Bioinformatics Treatment Therapies

Coptisine inhibits the malignancy of bladder carcinoma cells and regulates XPO1 expression

Chemical Biology and Drug Design

JULY 13, 2023

Bioinformatics analysis was performed to predict the molecular targets of COP. This study showed that COP treatment markedly suppressed the malignant biological behaviors of bladder carcinoma cells. COP treatment modulated the expression level of cyclin D1 and CYP450 via XPO1.

Regulations

Regulations Bioinformatics Treatment Drugs

Thalidomide suppresses migration and invasion of colorectal cancer cells by inhibiting HOXB7?mediated activation of the Wnt/??catenin signaling pathway

Chemical Biology and Drug Design

JANUARY 5, 2024

Following the treatment of 0, 1.94, 7.75, or 19.36 μM Homeobox B7 (HOXB7) expression in CRC was analyzed and detected by bioinformatics analysis, quantitative real-time PCR or western blot. Homeobox B7 (HOXB7) expression in CRC was analyzed and detected by bioinformatics analysis, quantitative real-time PCR or western blot.

Bioinformatics

Bioinformatics Cell Biology Treatment Research

Acacetin restrains the malignancy of esophageal squamous carcinoma cells via regulating JAK2/STAT3 pathway

Chemical Biology and Drug Design

JULY 4, 2023

Acacetin may be a promising drug in complementary therapy of cancer treatment. Genes related to acacetin and esophageal cancer were predicted by bioinformatics analysis. Acacetin treatment induced bax's expression and repressed bcl-2's expression.

Bioinformatics

Bioinformatics Regulations Treatment Therapies

HSYA prevents IL?1??induced human chondrocyte damage in osteoarthritis by inhibiting NF??B activation

Chemical Biology and Drug Design

FEBRUARY 7, 2024

The gene expression of the extracellular matrix was revealed by q-PCR 24 h after IL-1β treatment. We assessed the effect of HSYA and NF-κB signaling pathway-related genes by bioinformatics analysis and conducted molecular docking to assess the interaction of HSYA with a combined protein residue molecule ligand. 10, 40, and 160 μM).

Bioinformatics

Bioinformatics Treatment Production Disease

Plumbagin induces apoptosis, cell cycle arrest, and inhibits protein synthesis in LoVo colon cancer cells: A proteomic analysis

Chemical Biology and Drug Design

AUGUST 9, 2023

The LC-MS/MS proteomics assay revealed 78 proteins that were differentially expressed upon treatment with plumbagin. Bioinformatics and functional analyses indicated that these proteins were predominantly involved in protein synthesis and translation.

Bioinformatics

Bioinformatics Protein Expression Treatment Research

Identification of a 2?phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells

Chemical Biology and Drug Design

NOVEMBER 27, 2023

GO and KEGG enrichment analysis showed A6 treatment mainly disrupted sterol/cholesterol pathway, Ras signaling pathway, VEGF signaling pathway, etc. Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ.

Bioinformatics

Bioinformatics RNA Regulations Therapies

Can Global Genomic Surveillance Forecast the Next Pandemic?

PLOS: DNA Science

MAY 16, 2024

Other genomic databases were retooled for the huge datasets that COVID was generating, such as the Cloud Institute for Microbial Bioinformatics, begun in 2014 and rechristened the COVID-19 Genomics UK Consortium ( COG-UK ). • reveals viral vulnerability to inspire novel treatments. It closed a year ago.

Virus

Virus DNA RNA Laboratories

Scientific workflow for hypothesis testing in drug discovery: Part 1

Drug Target Review

DECEMBER 6, 2024

This article outlines the various stages of such a workflow, from hypothesis generation to data cleaning and interpretation, referencing the project workflow diagram (Figure 1). At the heart of any research is the scientific question. Once the data has been cleaned, it is then subjected to descriptive analytics.

RNA

RNA Drugs Research Science

Article FDA Thank You Leaders at FDA share highlights and updates for drugs and biologics at RAPS Convergence

Agency IQ

OCTOBER 12, 2023

Joneckis said that CBER has “some limited uses that we have seen in external submissions, mostly in the bioinformatics area,” but not as many as CDER. Regarding artificial intelligence (AI), an important topic at RAPS Convergence, the two centers discussed external and internal use cases.

FDA

FDA Clinical Trials International Drugs

Next Generation Sequencing (NGS) in Clinical Trials: Challenges and Opportunities

Vial

DECEMBER 5, 2023

Precision medicine and clinical trial design NGS is critical to the development of precision oncology treatment , e.g., targeted therapy, which uses cancer genome profiling to identify the mutation and select the best intervention. This will enable a deeper understanding of cellular processes, disease mechanisms, and personalized treatment.

Clinical Trials

Clinical Trials Trials RNA Bioinformatics

Codon Digest: GPT-4 Controls a Robot

Codon

APRIL 16, 2023

BMC Bioinformatics. Read There’s a news article that breaks down this work. Read Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice. Read Deep learning of genomic contexts predicts protein co-regulation and function. McCafferty C.L.

Engineering

Engineering DNA RNA Science

Drug Discovery Digest

ANKRD22 promotes M2 polarization in lung adenocarcinoma macrophages via the glycolytic pathway

The first major set of genetic associations found in long COVID

Trending Sources

Brusatol induces ferroptosis to inhibit hepatocellular carcinoma progression by targeting ATF3

Coptisine inhibits the malignancy of bladder carcinoma cells and regulates XPO1 expression

Thalidomide suppresses migration and invasion of colorectal cancer cells by inhibiting HOXB7?mediated activation of the Wnt/??catenin signaling pathway

Acacetin restrains the malignancy of esophageal squamous carcinoma cells via regulating JAK2/STAT3 pathway

HSYA prevents IL?1??induced human chondrocyte damage in osteoarthritis by inhibiting NF??B activation

Plumbagin induces apoptosis, cell cycle arrest, and inhibits protein synthesis in LoVo colon cancer cells: A proteomic analysis

Identification of a 2?phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells

Can Global Genomic Surveillance Forecast the Next Pandemic?

Scientific workflow for hypothesis testing in drug discovery: Part 1

Article FDA Thank You Leaders at FDA share highlights and updates for drugs and biologics at RAPS Convergence

Next Generation Sequencing (NGS) in Clinical Trials: Challenges and Opportunities

Codon Digest: GPT-4 Controls a Robot

Stay Connected