Chemical Biology and Drug Design

JANUARY 5, 2024

Following the treatment of 0, 1.94, 7.75, or 19.36 μM Homeobox B7 (HOXB7) expression in CRC was analyzed and detected by bioinformatics analysis, quantitative real-time PCR or western blot. Homeobox B7 (HOXB7) expression in CRC was analyzed and detected by bioinformatics analysis, quantitative real-time PCR or western blot.

Bioinformatics 100

Bioinformatics Cell Biology Treatment Research 100

Chemical Biology and Drug Design

AUGUST 9, 2023

The LC-MS/MS proteomics assay revealed 78 proteins that were differentially expressed upon treatment with plumbagin. Bioinformatics and functional analyses indicated that these proteins were predominantly involved in protein synthesis and translation.

Bioinformatics 100

Bioinformatics Protein Expression Treatment Research 100

Chemical Biology and Drug Design

NOVEMBER 27, 2023

GO and KEGG enrichment analysis showed A6 treatment mainly disrupted sterol/cholesterol pathway, Ras signaling pathway, VEGF signaling pathway, etc. Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ.

Bioinformatics 100

Bioinformatics RNA Regulations Therapies 100

Chemical Biology and Drug Design

FEBRUARY 7, 2024

The gene expression of the extracellular matrix was revealed by q-PCR 24 h after IL-1β treatment. We assessed the effect of HSYA and NF-κB signaling pathway-related genes by bioinformatics analysis and conducted molecular docking to assess the interaction of HSYA with a combined protein residue molecule ligand. 10, 40, and 160 μM).

Bioinformatics 100

Bioinformatics Treatment Production Disease 100

Drug Target Review

DECEMBER 6, 2024

This article outlines the various stages of such a workflow, from hypothesis generation to data cleaning and interpretation, referencing the project workflow diagram (Figure 1). At the heart of any research is the scientific question. Once the data has been cleaned, it is then subjected to descriptive analytics.

RNA 52

RNA Drugs Research Science 52

PLOS: DNA Science

MAY 16, 2024

Other genomic databases were retooled for the huge datasets that COVID was generating, such as the Cloud Institute for Microbial Bioinformatics, begun in 2014 and rechristened the COVID-19 Genomics UK Consortium ( COG-UK ). • reveals viral vulnerability to inspire novel treatments. It closed a year ago.

Virus 98

Virus DNA RNA Science 98

Agency IQ

OCTOBER 12, 2023

Joneckis said that CBER has “some limited uses that we have seen in external submissions, mostly in the bioinformatics area,” but not as many as CDER. Regarding artificial intelligence (AI), an important topic at RAPS Convergence, the two centers discussed external and internal use cases.

FDA 40

FDA Clinical Trials International Drugs 40

Vial

DECEMBER 5, 2023

Precision medicine and clinical trial design NGS is critical to the development of precision oncology treatment , e.g., targeted therapy, which uses cancer genome profiling to identify the mutation and select the best intervention. This will enable a deeper understanding of cellular processes, disease mechanisms, and personalized treatment.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

Chemical Biology and Drug Design

MARCH 4, 2025

Network pharmacology and bioinformatics analysis showed that the role of FA in treating IS was associated with oxidative stress. FA treatment could significantly reduce cerebral infarction, cerebral edema, neurological function impairment, and neuronal injury of the rats with MCAO/R.

Bioinformatics 100

Bioinformatics Treatment Drugs Research 100

Drug Target Review

FEBRUARY 11, 2025

These hurdles not only delay patient access to innovative treatments but also threaten the economic sustainability of research and development (R&D) and the advancement of medical innovation. These failures not only increase overall costs, but also slow down scientific progress, delaying potential treatments for patients.

Drug Development 59

Drug Development Bioinformatics Drugs Small Molecule 59

Drug Target Review

MARCH 13, 2025

The development of targeted drugs for genetically defined patient subgroups has significantly improved the efficacy of treatments, while reducing the risks of adverse effects. With a more accurate selection of targets and better stratification of patients, many failures that previously occurred in the clinical phases can be prevented.

Drug Development 59

Drug Development Clinical Trials Science FDA 59

Codon

APRIL 16, 2023

BMC Bioinformatics. Read There’s a news article that breaks down this work. Read Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice. Read Deep learning of genomic contexts predicts protein co-regulation and function. McCafferty C.L.

Engineering 52

Engineering DNA RNA Science 52