Broad Institute

JUNE 30, 2023

New image-based cellular profiling tool peers deeply into metabolic biology By Makenzie Kohler June 30, 2023 Breadcrumb Home New image-based cellular profiling tool peers deeply into metabolic biology LipocyteProfiler captures disease-relevant phenotypes in an inexpensive microscopy assay By Makenzie Kohler June 30, 2023 Credit: Phil Kubitz, Claussnitzer (..)

Small Molecule 105

Small Molecule Cell Based Assays Disease Assay Development 105

Molecular Design

DECEMBER 31, 2023

My main criticism of BW2014 that is that the rhetoric is not supported by data and I’ve always seen the article as something of a propaganda piece. I was rather surprised that BW2014 had not cited a single article about how colloidal aggregation can foil drug discovery. Given that M2003 had been published over a decade previously.

Drugs 96

Drugs Packaging Cell Based Assays Small Molecule 96

Molecular Design

NOVEMBER 19, 2023

The authors of S2023 claim to have revealed “suboptimal use of chemical probes in cell-based biomedical research” and I’ll start by taking a look at the abstract (my annotations are italicised in red): Chemical probes have reached a prominent role in biomedical research, but their impact is governed by experimental design.

Cell Based Assays 71

Cell Based Assays Research Compliance Laboratories 71

Molecular Design

DECEMBER 19, 2023

I’ll be taking a look at H2023 (Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes) in this post and this article has also been discussed In The Pipeline. Subscripting doesn't work well in blogger and so I'll use K.i As measurement of k.inact/K.i

Small Molecule 65

Small Molecule Biochemical Assays Cell Based Assays Drugs 65

Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

Production 40

Production FDA Therapies Biochemical Assays 40

Molecular Design

JUNE 8, 2023

My view is that the data analysis presented in L2021 has minimal relevance to drug discovery so I’ll be saying rather less about the data analysis than I’d have done had J Med Chem asked me to review the study.

Cell Based Assays 62

Cell Based Assays Small Molecule Drugs Marketing 62

Drug Target Review

OCTOBER 24, 2024

Data-driven discovery As with many early-stage biotech companies, Five Alarm Bio is highly data-driven, producing vast amounts of experimental data through cell-based assays and phenotypic screening. She founded Pellis Care Ltd and in 2022 joined Five Alarm Bio Ltd as CEO.

Cell Based Assays 52

Cell Based Assays Science Disease Doctors 52