Broad Institute
JUNE 30, 2023
New image-based cellular profiling tool peers deeply into metabolic biology By Makenzie Kohler June 30, 2023 Breadcrumb Home New image-based cellular profiling tool peers deeply into metabolic biology LipocyteProfiler captures disease-relevant phenotypes in an inexpensive microscopy assay By Makenzie Kohler June 30, 2023 Credit: Phil Kubitz, Claussnitzer (..)
Molecular Design
DECEMBER 31, 2023
My main criticism of BW2014 that is that the rhetoric is not supported by data and I’ve always seen the article as something of a propaganda piece. I was rather surprised that BW2014 had not cited a single article about how colloidal aggregation can foil drug discovery. Given that M2003 had been published over a decade previously.
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Drug Target Review
MAY 3, 2024
Large language models are exceptional at collecting vast amounts of disparate information from esoteric websites, forums, book chapters, review articles, and even open access journals and then cramming the sum total of that information into a plain language summary that does a fair job of approximating human knowledge on the subject.
Molecular Design
DECEMBER 19, 2023
I’ll be taking a look at H2023 (Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes) in this post and this article has also been discussed In The Pipeline. Subscripting doesn't work well in blogger and so I'll use K.i As measurement of k.inact/K.i
Agency IQ
APRIL 12, 2024
Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).
Molecular Design
JUNE 8, 2023
My view is that the data analysis presented in L2021 has minimal relevance to drug discovery so I’ll be saying rather less about the data analysis than I’d have done had J Med Chem asked me to review the study.
Drug Target Review
OCTOBER 24, 2024
Data-driven discovery As with many early-stage biotech companies, Five Alarm Bio is highly data-driven, producing vast amounts of experimental data through cell-based assays and phenotypic screening. She founded Pellis Care Ltd and in 2022 joined Five Alarm Bio Ltd as CEO.
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