Molecular Design

DECEMBER 31, 2023

My main criticism of BW2014 that is that the rhetoric is not supported by data and I’ve always seen the article as something of a propaganda piece. Interference with read-out and undesirable MoAs are very different problems in drug discovery and the failure to recognize this point is a serious deficiency that is shared by BW2014 and BH2010.

Drugs 96

Drugs Packaging Cell Based Assays Small Molecule 96

Broad Institute

JUNE 30, 2023

The researchers also looked at the tool’s ability to detect changes in cellular phenotypes after exposure to drugs and small molecule compounds. Typically, studying drug therapies is an expensive and time-consuming undertaking.

Small Molecule 105

Small Molecule Cell Based Assays Disease Assay Development 105

Drug Target Review

MAY 3, 2024

Another good example is really any process optimization / screening domain, whether it’s cloning screening, media formulation, drug screens, etc. At Beckman Coulter Life Sciences , he supports the applications development team in NGS, cell-based assays, and proteomics workflows.

Research 116

Research Science Cell Based Assays Disease 116

Molecular Design

JUNE 8, 2023

I’ll start the review of L2021 with annotation of the abstract: "Physicochemical descriptors commonly used to define ‘drug-likeness’ and ligand efficiency measures are assessed for their ability to differentiate marketed drugs from compounds reported to bind to their efficacious target or targets. [I

Cell Based Assays 62

Cell Based Assays Small Molecule Drugs Marketing 62

Molecular Design

DECEMBER 19, 2023

I’ll be taking a look at H2023 (Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes) in this post and this article has also been discussed In The Pipeline. This Perspective is intended to jumpstart this important scientific discussion. Subscripting doesn't work well in blogger and so I'll use K.i

Small Molecule 65

Small Molecule Biochemical Assays Cell Based Assays Drugs 65

Molecular Design

SEPTEMBER 18, 2024

Different assay organism or cell types: the target protein may be recombinantly expressed in different cell types (the target ID in ChEMBL is assigned based on the original source of the target), or the assays may be run using different cell types.

Biochemical Assays 68

Biochemical Assays Drugs Biophysical Assays Cell Based Assays 68

Molecular Design

MARCH 26, 2024

Encountering words like “truth” and “beauty” (here's a good example ) in the titles of scientific articles always sets off warning bells for me and I’ll kick off blogging for 2024 with a look at FM2024 (Structure is beauty, but not always truth) that was recently published in Cell.

Drugs 60

Drugs Pharmacokinetics Cell Based Assays Treatment 60