Broad Institute

JUNE 30, 2023

The researchers also looked at the tool’s ability to detect changes in cellular phenotypes after exposure to drugs and small molecule compounds. With high-resolution, cell-based profiling techniques, extracting a large amount of data can be done cheaply and efficiently.

Small Molecule 105

Small Molecule Cell Based Assays Disease Assay Development 105

Molecular Design

DECEMBER 19, 2023

I’ll be taking a look at H2023 (Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes) in this post and this article has also been discussed In The Pipeline. Subscripting doesn't work well in blogger and so I'll use K.i I’ll start with Section 2.1 As measurement of k.inact/K.i

Small Molecule 65

Small Molecule Biochemical Assays Cell Based Assays Drugs 65

Molecular Design

DECEMBER 31, 2023

My main criticism of BW2014 that is that the rhetoric is not supported by data and I’ve always seen the article as something of a propaganda piece. I was rather surprised that BW2014 had not cited a single article about how colloidal aggregation can foil drug discovery. Given that M2003 had been published over a decade previously.

Drugs 96

Drugs Packaging Cell Based Assays Small Molecule 96

Molecular Design

JUNE 8, 2023

Nevertheless, those small molecule drug properties that show consistent differentiation from their target compounds over time, namely, potency, ligand efficiencies (LE and LLE), and the aromatic ring count and lipophilicity of carboaromatic drugs, are those that are most likely to remain future-proof.

Cell Based Assays 62

Cell Based Assays Small Molecule Drugs Marketing 62