article thumbnail

#ScienceSaturday: March 2, 2024

KIF1A

Read the Article Rare Roundup The Jackson Laboratory offers “Exploring Rare Disease Through Translational Research” MiniCourse Human health is incredibly complex; developing safe, effective treatments requires knowledge of molecular mechanisms, cell biology, and drug administration.

article thumbnail

Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development. The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0”

Disease 98
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Thalidomide suppresses migration and invasion of colorectal cancer cells by inhibiting HOXB7?mediated activation of the Wnt/??catenin signaling pathway

Chemical Biology and Drug Design

After the corresponding transfection or treatment with inhibitor of catenin-responsive transcription-3 (iCRT-3), abovementioned CRC cell biological behaviors as well as expression levels of HOXB7 and β-catenin were evaluated. μM THA dwindled CRC cell viability, migration, and invasion, and facilitated apoptosis.

article thumbnail

Optimising CRIPSR gene editing of hard-to-transfect cells

Drug Target Review

With its disruptive pipetting technology, SEED Biosciences is bridging the gap between the capabilities in liquid handling and the opportunities in single cell biology. He is the recipient of multiple awards for young entrepreneurs, including the Venture Leaders Prize given to top Swiss entrepreneurs.

article thumbnail

MicroRNA?577/EIF5A2 axis suppressed the proliferation of DDP?resistant nasopharyngeal carcinoma cells by blocking TGF?? signaling pathway

Chemical Biology and Drug Design

DDP-resistant NPC cells were established by treatment with DDP at increased concentrations (2, 4, 6, 8, or 10 μg/mL). Cell biological behaviors were assessed via cell function experiments. MicroRNA-577 and EIF5A2 mRNA expressions were detected by qRT-PCR.

article thumbnail

A Defense of Peer Review

Codon

Similar sentiments have been expressed elsewhere, such as by Brandon Stell, the founder of PubPeer , a website where anyone can leave comments about academic articles. Still, shortly after I read Mastroianni’s article, Ben Recht asked on Twitter if there were any articles presenting “a positive case for peer review.”

Science 110
article thumbnail

Optimising CRISPR gene editing of hard-to-transfect cells

Drug Target Review

With its disruptive pipetting technology, SEED Biosciences is bridging the gap between the capabilities in liquid handling and the opportunities in single cell biology. He is the recipient of multiple awards for young entrepreneurs, including the Venture Leaders Prize given to top Swiss entrepreneurs.