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#ScienceSaturday: March 2, 2024

KIF1A

Read the Article Rare Roundup The Jackson Laboratory offers “Exploring Rare Disease Through Translational Research” MiniCourse Human health is incredibly complex; developing safe, effective treatments requires knowledge of molecular mechanisms, cell biology, and drug administration.

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Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development. Dewpoint Therapeutics, a platform drug discovery company founded in 2018, has been at the forefront of this exciting field.

Disease 98
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Scientists uncover a new approach for treating aggressive cancer

The Pharma Data

Their findings are published online in Nature Cell Biology. “We are amazed by the efficiency of small-molecule PROTAC in simultaneously targeting EZH2 and cMyc in cancer cells.”

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Discovering an Antimalarial Drug in Mao’s China

Codon

Department of Defense administered mefloquine, the synthetic drug developed at Walter Reed in the U.S., only issued “the strongest ‘black box’ warning” against the drug in 2013. Few journal articles were written about the project using her (or anyone’s) name before 2010. Nobody had an answer.

Drugs 129
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Precision Medicine in the Genomic Era

DrugBank

The general notion is that patients should be viewed individually, rather than strictly as members of some larger general population, and that their specific genetic background, environment, and lifestyle choices should be considered throughout drug development to the point of treatment and continuing patient care.

Disease 88