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In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development. The aim is to establish condensate biology as a fundamental branch of cellbiology – “cellbiology 2.0”
Shortly after finishing my studies, I landed my first job in industry working on cellbiology research for several disease indications. I would keep track of developments in the industry through research articles, conferences and my network. Kymera has advanced the first degrader into the clinic for immunological diseases.
They then developed a new therapeutic approach with a potent small-molecule inhibitor of this enzyme. Certain subtypes of blood cancers such as acute leukemias rely on multiple mechanisms for sustaining growth of aggressive cancer cells. Their findings are published online in Nature CellBiology.
This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. ” — Samuel Butler , 1878 (* = My picks) AI + Bio Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning. Cell Systems. Thanks for skimming.
Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature CellBiology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Cell Systems.
Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature CellBiology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Cell Systems.
Read There’s a news article that breaks down this work. Nature CellBiology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Read Just for Fun High protein-containing new food by cell powder meat. Favate J.S. Debès C. Rockweiler N.B. Nature Biotechnology.
Traditionally, drug discovery has focused on small-molecule therapeutics, typically with a molecular weight of less than 500 Daltons. 2 Typically, small-molecule drugs target active sites buried inside proteins. What are macrocycles and why are they interesting for drug discovery?
Likarda initially developed CSS to overcome the lack of effective delivery systems for cell therapies. It subsequently demonstrated promise for the administration of peptides, monoclonal antibodies and smallmolecules. Table 2 compares the characteristics of the microbead hormones with the other administration methods.
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