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Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development. The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0”

Disease 98
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Women in STEM with Juliet Williams

Drug Target Review

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. I would keep track of developments in the industry through research articles, conferences and my network. Kymera has advanced the first degrader into the clinic for immunological diseases.

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Scientists uncover a new approach for treating aggressive cancer

The Pharma Data

They then developed a new therapeutic approach with a potent small-molecule inhibitor of this enzyme. Certain subtypes of blood cancers such as acute leukemias rely on multiple mechanisms for sustaining growth of aggressive cancer cells. Their findings are published online in Nature Cell Biology.

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Codon Digest: Injected Gene Editors

Codon

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. ” — Samuel Butler , 1878 (* = My picks) AI + Bio Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning. Cell Systems. Thanks for skimming.

DNA 52
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Codon Digest: Vaccine Printer Go Brrrrr!

Codon

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Cell Systems.

Vaccine 52
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Codon Digest: Vaccine Printer Go Brrrrr!

Codon

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Cell Systems.

Vaccine 52
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Codon Digest: GPT-4 Controls a Robot

Codon

Read There’s a news article that breaks down this work. Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Read Just for Fun High protein-containing new food by cell powder meat. Favate J.S. Debès C. Rockweiler N.B. Nature Biotechnology.