Article Disease Protein Expression 
Chemical Biology and Drug Design
FEBRUARY 15, 2024
Abstract Dry eye (DE) is a multifactorial ocular surface disease characterised by an imbalance in tear homeostasis. However, the DE disease pathogenesis remains unclear, thereby affecting its clinical treatment. PGE2 was highly expressed in the DE mouse model. T helper 17 cells) and other factors.
Chemical Biology and Drug Design
JANUARY 5, 2024
Remimazolam suppressed NLRP3 activity to reduce inflammation level in model of bronchopneumonia by the inhibition of PDPK1 ubiquitination by interlinked PDPK1 protein, as a novel drug for inflammation in model of bronchopneumonia or other pulmonary disease. Remimazolam interlinked PDPK1 protein.
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Chemical Biology and Drug Design
SEPTEMBER 25, 2023
Vinp treatment promotes Wnt proteins to connect the receptors complex on the cell membrane (consisting of FZD and LRP5/6), and then β-catenin is subsequently dissociated from the complex and translocated to the nucleus, activating transcription of downstream target genes. It reduces motor and cognitive function in patients.
Drug Discovery World
NOVEMBER 27, 2023
This article is sponsored by Revvity. As the significance of large molecules continues to broaden across diverse modalities, emphasis on bispecific and multispecific antibodies to treat various disorders such as rheumatologic diseases, cancer, diabetes, anaemia, and infectious diseases becomes paramount.
Chemical Biology and Drug Design
MARCH 5, 2024
The results showed that CA-COS inhibited nitric oxide (NO) production and downregulated the gene expression of nitric oxide synthase (iNOS), and cytokines such as tumor necrosis factor-alpha (TNF-α), IL-1β, and IL-6 without cytotoxic effect.
Chemical Biology and Drug Design
DECEMBER 6, 2023
Target genes of SP-FC were obtained from the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), and targets of HS-related diseases were searched from databases such as Disgenet and GeneCards. was employed for protein–protein interaction (PPI) network analysis of common targets; and cytoscape 3.9.0
The Anticancer Fund
SEPTEMBER 29, 2021
Being listed is no endorsement of the results and conclusions of the article. All articles need to be critically assessed and viewed in their broader research context. This drug combination is rationally designed to target multiple escape mechanisms by which refractory disease evades treatment.
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