KIF1A

JANUARY 20, 2024

In this week’s article, researchers in Shanghai, China identified 6 children with KIF1A mutations and compared their symptoms to cases in the literature. Instead, this is what is called a splicing mutation; it occurs at the boundary between coding DNA that is read into RNA and protein, and noncoding DNA that is excluded.

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KIF1A

APRIL 6, 2024

When a mutation causes a deletion or duplication of larger areas of DNA, we call it Copy Number Variation. DNA deletion and duplication may impact large sections of genes, or multiple neighboring genes. Read the Article The post #ScienceSaturday: April 6, 2024 appeared first on KIF1A.

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DNA Medical Schools Therapies Research 111

PLOS: DNA Science

SEPTEMBER 19, 2024

And discovering the DNA sequence of a novel genome intrigues me in much the same way as those ancient worm borings did, but it’s even more telling, because genetic information reveals clues to the past and connects the ancient species to their modern descendants.

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DNA Science Research 90

PLOS: DNA Science

APRIL 20, 2023

DNA is a sleek double helix, with “rungs” consisting of a purine base paired with a smaller pyrimidine base: adenine (A) with thymine (T) and guanine (G) with cytosine (C). . ” DNA encodes amino acid sequences comprising proteins, which impart traits. Watson and F.

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Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. We’ve miniaturised the chemical process to making DNA and synthesize or ‘write’ DNA on a silicon chip.

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DNA Organic Chemistry Science Virus 116

PLOS: DNA Science

MAY 16, 2024

Many of the links below are to some of the 100+ DNA Science posts that I wrote during the pandemic. • Long-read RNA and DNA sequencing technologies have improved speed and accuracy by analyzing long stretches of the nucleic acids, compared to the small pieces that fueled earlier sequencing methods. • Single-cell sequencing.

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Drug Target Review

DECEMBER 21, 2023

Within the pages of this publication, readers will find in-depth articles that elucidate the latest advancements, challenges, and breakthroughs within the field of drug discovery. This issue encompasses a spectrum of topics, including proteomics, upstream bioprocessing, immuno-oncology, CRISPR and screening.

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Drugs DNA Engineering Disease 98

Agency IQ

JULY 21, 2023

The next chapter in the ctDNA story: Still promising, not ready for prime time A recent workshop summed up the state of play for circulating tumor DNA. Fill out the form to read the full article.

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FDA FDA Approval DNA Production 52

KIF1A

JANUARY 13, 2024

As one cell turns into two, its DNA must be replicated and then pulled apart, so that when the cell divides each has all the DNA it needs to function. The strands that pull the DNA apart are composed of microtubules, and kinesins like KIF1A and KIF13B can impact the direction the strands pull in.

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DNA Regulations Drug Development Disease 105

Chemical Biology and Drug Design

SEPTEMBER 16, 2024

This study identified MAPK9 as the directly binding target of baicalein by the DNA-programmed affinity labeling method and tested the binding affinity as 89.7 nM Therefore, we used the DNA-programmed affinity labeling method to identify the target of baicalein and validated its function in HCC cells. nM by surface plasmon resonance.

DNA 100

DNA Therapies Treatment Production 100

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

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PLOS: DNA Science

SEPTEMBER 7, 2023

As genetics morphed into genomics, artificial intelligence stepped in, layering the combinatorial information of comparative genomics onto DNA sequences. Train an algorithm on the DNA sequences of a known disease-causing gene, then search for identical or highly similar sequences in cells from other individuals to assist diagnosis.

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DNA Science Therapies Licensing 98

Chemical Biology and Drug Design

NOVEMBER 23, 2023

There are challenges in delivering the gene/DNA to the site of action in the brain, and scientists are working to resolve the same. The present article describes the basics regarding the disease, its causes and factors responsible, and the gene therapy solutions available to treat this disease.

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Therapies DNA Regulations Disease 100

KIF1A

JANUARY 27, 2024

Rare Roundup KRIBB develops new gene therapy candidate for hereditary spastic paraplegia This week we’re flipping the format and starting with our Rare Roundup, after families contacted us with this article about a gene therapy candidate for hereditary spastic paraplegia.

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Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Sign up to get articles from Asimov Press.

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DNA Engineering RNA Small Molecule 83

Chemical Biology and Drug Design

SEPTEMBER 28, 2023

Abstract Proliferating cell nuclear antigen (PCNA) is a homo-trimeric protein complex that clamps around DNA to tether DNA polymerases to the template during replication and serves as a hub for many other interacting proteins. This is the proof-of concept for a novel T. brucei

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Small Molecule DNA Regulations Research 100

PLOS: DNA Science

NOVEMBER 16, 2023

Here at DNA Scienc e a few years ago, I shared The Peaceable Genomes of Pumpkins. For this year’s Thanksgiving post, I came upon an article, Genomic Prediction and Selection for Fruit Traits in Winter Squash, published in G3: Genes, Genomes, and Genetics , from Michael R Mazourek of Cornell University and colleagues, from 2020.

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DNA Science Disease Research 98

PLOS: DNA Science

JUNE 27, 2024

After all, they can reproduce even under radiation levels 1,000 times that which would kill a human, possessing admirable DNA repair skills. An article in Scientific Reports from 2017 points out that tardigrades could be the sole surviving species of a global environmental disaster.

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KIF1A

MAY 4, 2024

In this week’s article, researchers in Brazil identified a KIF1A mutation in a cohort of patients with congenital ataxia. Her undergraduate research focused on lipid metabolism of NASH at UCSD Medical School and DNA breakage and repair mechanism at Scripps Research. She graduated from UC San Diego with a B.S.

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Alta Sciences

FEBRUARY 19, 2025

An oligonucleotide is a short strand of nucleotides, the building blocks of DNA or RNA, used in genetic research and therapy. Our experts stay up to date on all new and evolving regulations to guarantee regulatory compliance in your studies. Have questions about your oligonucleotide therapeutic studies? Get in touch with our experts today.

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Chemical Biology and Drug Design

SEPTEMBER 18, 2023

The presence of partially occupied water molecules in the layered organization in the crystal structure mimics the release of reactive oxygen species (ROS) for DNA damage resulting in cytotoxicity.

Therapies 100

Therapies DNA Research 100

Chemical Biology and Drug Design

MAY 11, 2023

In our study of AGS cells, nuclear condensation was observed by 4′,6-diamidino-2-phenylindole (DAPI) staining, cell death was confirmed by a cell viability assay, and fragmented DNA was observed at the IC 50 dose by a DNA fragmentation assay. Apoptosis was evaluated by the qPCR technique.

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DNA Treatment Research 100

Codon

JUNE 30, 2024

Modern biotechnology began in 1972 when biochemists at Stanford University spliced together DNA from two different organisms. The race to exploit recombinant DNA technology was on. Chakrabarty genetically cross-linked the plasmids using X-rays and then placed the newly assembled sequence into Pseudomonas putida.

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Codon

DECEMBER 12, 2024

” The report accompanies an article in Science , also released today, entitled “Confronting Risks of Mirror Life.” For the article in Science , more than 30 scientists from ten countries are calling on the broader community to confront the risks of mirrored life. ” But what, exactly, is a mirrored organism?

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Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

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Codon

JUNE 25, 2024

This article is part of Issue 03. However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. However, E. Thus, each round of cloning takes at least three days of work.

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DNA RNA Laboratories Research 80

Chemical Biology and Drug Design

DECEMBER 13, 2024

DNA G-quadruplexes (G4) have emerged as potential regulatory targets for c-Myc expression. ABSTRACT Overexpression of c-Myc is a key factor in the development of leukemia and other malignancies, highlighting the urgent need for novel drugs to inhibit c-Myc protein levels.

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DNA Therapies Drugs Research 100

Drug Target Review

MAY 24, 2024

More explanation and practical tips for using these technologies will be explored in future articles. 2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). These are foundational to drug discovery and will be discussed in future articles. Alphafold 3.0: the AI protein predictor gets an upgrade.

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RNA DNA Bioinformatics Science 59

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell.

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Codon

JUNE 13, 2024

This is the first article in our new column. billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end. By way of comparison, with 3.1 Next came the fun part.

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DNA Molecular Biology Virus Cell Biology 60

Codon

AUGUST 26, 2024

Sign up to receive new articles from Asimov Press. DNA delivered to the nose or lungs can express an encoded protein for months to over a year in mice if the vector—the “backbone” of DNA-based medicines controlling the level and timing of expression of the encoded protein—is specifically engineered to be long-lasting.

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Codon

MAY 18, 2023

shelves, it’s easy to find DNA in the air , and some weird insect cybernetics. The company behind the tomato, Sanatech Seeds , claims that eating GABA can help relieve stress and lower blood pressure," the WIRED article says. And the article doesn’t mention how Pairwise engineered the mustard to be “less pungent.”

DNA 52

DNA Therapies Engineering Virus 52

Codon

MAY 18, 2023

shelves, it’s easy to find DNA in the air , and some weird insect cybernetics. The company behind the tomato, Sanatech Seeds , claims that eating GABA can help relieve stress and lower blood pressure," the WIRED article says. And the article doesn’t mention how Pairwise engineered the mustard to be “less pungent.”

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DNA Therapies Engineering Virus 52

Chemical Biology and Drug Design

NOVEMBER 22, 2022

Gel electrophoresis revealed that the experimental groups had more fragmented DNA than the control group. Gene expression was revealed by RT-qPCR, and the fold ratio of Apaf-1, cytochrome-c, caspase-9, caspase-3, and Bax genes' expression was raised in treated groups, implying apoptosis. The study shows that a phospholipid extract from S.

DNA 100

DNA Research 100

Chemical Biology and Drug Design

DECEMBER 12, 2024

Biochemical kits was utilized for checking the ATP, mitochondrial DNA, MDA, GSH, and Fe 2+ levels in the Huh7 cells, and western blot for measuring the ferroptosis and AMPK/mTOR related-protein expression levels.

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Protein Expression DNA Regulations Research 100

Agency IQ

AUGUST 11, 2023

In addition to claiming it was mandatory to take account of EFSA’s conclusions, article 17 of the Plant Protection Products Regulation (PPPR) (1107/2009/EC) was referenced as rationale for prolonging approval when a decision can’t be made by the expiration date.

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The Premier Consulting Blog

MARCH 7, 2024

Depending on the gene therapy vector, microbial systems may be employed to produce vector DNA (such as in adeno associated virus (AAV)), in which case there may be bacterial cell banks and plasmid banks. A more rigorous identity test may sometimes be required, such as DNA sequencing of the entire AAV genome.

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