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MiR?34 by targeting p53 induces apoptosis and DNA damage in paclitaxel?resistant human oral squamous carcinoma cells

Chemical Biology and Drug Design

The chemosensitive effects of miR-34 is mediated through increasing DNA damage and apoptosis in a p53 depended manner. The present study aimed to evaluate the effects of miR-34 restoration in OECM-1 oral cancer resistant to paclitaxel (OECM-1/PTX) and its underlying mechanisms through p53-mediated DNA damage and apoptosis.

DNA 100
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Five Promising Treatment Areas in Early-Phase Drug Development in 2024

Alta Sciences

In this blog article, we review some of these areas of investigation where Altasciences has robust expertise and solution offerings. According to a 2022 article published in Molecular Psychiatry, treatment resistance affects 20 to 60% of patients with psychiatric disorders. Asia, and Europe.

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Key considerations before commencing cell line development

Drug Target Review

A good introduction to the use of CHO cells for biotherapeutics production can be found in an article commemorating the 20th anniversary of the approval of a product produced using CHO cells. These sites are typically in areas of open chromatin and associated with highly expressed genes. Biotechnol. 2022), 349: 53-64.

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Codon Digest: CAR-T Therapy for Neuroblastoma

Codon

.” This technology could be used to design protein therapeutics that can bind to, and “shut down,” harmful or misfolded proteins in living cells. Thousands of transcription factors — proteins that bind DNA and control gene expression — were studied in human cells. Bergs A.C.F.