Chemical Biology and Drug Design

MARCH 12, 2025

Therefore, it is an important target for antibacterial drug research. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis. Although many MurA inhibitors have been discovered, only fosfomycin is still used as a MurA inhibitor in clinical practice.

Drug Research 100

Drug Research Research Drugs 100

Chemical Biology and Drug Design

JULY 5, 2024

Abstract Intestinal absorption of compounds is significant in drug research and development. The QSPR model accurately predicted the intestinal absorption of molecules, and the computer simulation found the mechanism of molecular structure affecting intestinal absorption.

Drug Research 100

Drug Research Research Drugs 100

Agency IQ

JUNE 7, 2024

According to the fiscal year 2023 metrics (the most recent available), the BIMO program conducted over 1,000 inspections in FY 2023, with most (779) for CDER-regulated products.

FDA 40

FDA Compliance Regulations Production 40

Chemical Biology and Drug Design

FEBRUARY 25, 2025

Together, the present study systematically clarified the possible mechanisms of RES in the treatment of CRS and provided new ideas for the drug research of this disease. A variety of results from cell experiments verified that RES can effectively inhibit the inflammation, oxidative stress and apoptosis of LPS-induced HNEpCs.

Treatment 100

Treatment Disease Drug Research Research 100

Agency IQ

NOVEMBER 27, 2023

These API-derived nitrosamines are referred to as Nitrosamine Drug Substance Related Impurities (NDSRIs) and represent an unprecedented development with manufacturing, quality, and product safety implications. In a study of more than 12,000 small molecule drugs , researchers found 40.4%

Regulations 40

Regulations Production FDA Packaging 40

Agency IQ

JUNE 9, 2023

The problems: Although the current regulation stimulated orphan drug research, it didn’t do enough The regulation fostered development of medicines for rare diseases since implementation, but not enough. Article 81(2)(b) extends data exclusivity by 6 months for medicines addressing an unmet medical need, as orphan drugs do.

Marketing 40

Marketing Regulations Biosimilars Drugs 40

Agency IQ

AUGUST 2, 2024

(ACT EU) / Clinical Trials Coordination Groups (CTCG) 9/11/2024 9/11/2024 Public launch event on the guideline on good pharmacovigilance practices Module XVI on risk minimization measures and its Addendum II Webinar ( OPEN ) EMA 9/12/2024 9/12/2024 ENVI meeting Committee meeting ( OPEN ) Environment, Public Health and Food Safety (ENVI) 9/13/2024 9/13/2024 (..)

Regulations 40

Regulations Clinical Trials Production Trials 40