Codon

DECEMBER 12, 2024

” The report accompanies an article in Science , also released today, entitled “Confronting Risks of Mirror Life.” It would also be undetectable by key parts of the human immune system. ” But what, exactly, is a mirrored organism? To answer that, let’s consider how extant life works.

RNA 104

RNA DNA Vaccine Virus 104

Drug Target Review

JULY 11, 2023

In this article, I spoke to Olivia Cavlan, Chief Corporate Development and Strategy Officer at Alchemab Therapeutics Ltd, about how AI is transforming the landscape of disease research, unlocking a treasure trove of knowledge that may hold the key to a healthier future. Cavlan will explore more of these ends in our next article.

Disease 75

Disease RNA Small Molecule Clinical Development 75

Agency IQ

DECEMBER 1, 2023

The guidance also provided insight on new issues that had arisen since the first version of the guidance was published ; for example, the potential for drug resistance and the impact of virus shedding and immune response. These topics were covered in the body of the guidance and were addressed in two new appendices.

FDA 40

FDA Clinical Trials Vaccine Trials 40

Vial

DECEMBER 11, 2023

Hepatitis C virus (HCV) infection is a global health problem with complications that place a significant economic burden on national health systems. Related but genetically diverse virus variants can occur within the same infected patient, which may lead to quasispecies and resistance to antibody and T-cell-mediated immune responses.

Clinical Research 52

Clinical Research Therapies Research Vaccine 52

Codon

JULY 27, 2023

I could write an entire article in response, but if you want to go deeper into this subject, I suggest you read it in full. From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% a lower risk of immune responses. Gene-edited trees.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

I could write an entire article in response, but if you want to go deeper into this subject, I suggest you read it in full. From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% a lower risk of immune responses. Gene-edited trees.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

APRIL 30, 2023

In one experiment, the microneedle patches were used to deliver a SARS-CoV-2 vaccine into mice, producing immune responses similar to a traditional injection. Printed vaccines caused mice to have a faster immune response. Read A nice article from Aatish Bhatia about how A.I. But the printed vaccines are very good!

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

In one experiment, the microneedle patches were used to deliver a SARS-CoV-2 vaccine into mice, producing immune responses similar to a traditional injection. Printed vaccines caused mice to have a faster immune response. Read A nice article from Aatish Bhatia about how A.I. But the printed vaccines are very good!

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 9, 2023

Read Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine. Read An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses. The New England Journal of Medicine. McGrady N.R. Gene Therapy.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

APRIL 16, 2023

Skin microbes can trigger strong immune responses. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study. Favate J.S. Debès C. Rockweiler N.B.

Engineering 52

Engineering DNA RNA Science 52

PLOS: DNA Science

FEBRUARY 20, 2025

Influenza incidence and severity are increasing , against a backdrop of novel drifts (small genetic changes) and shifts (larger changes) to the virus, all against a backdrop of novel infection pathways, such as birds to cows to people. The mRNA in COVID vaccines tells cells to produce the virus’s spike protein.

Vaccine 94

Vaccine Science RNA Disease 94

PLOS: DNA Science

JULY 25, 2024

I’ve included links to some of my articles, where relevant. A virus that directly attacks the immune response presents a special challenge. The 1918 virus was H1N1, and the one behind a million deaths in 1957, H2N2. Possible spillover from the bird virus H5N1 is particularly alarming.

Virus 96

Virus Science Vaccine Government 96