Effect of ophiopogonin D on the pharmacokinetics and transport of cryptotanshinone during their co?administration and the potential mechanism
Chemical Biology and Drug Design
JUNE 8, 2023
The co-administration of cryptotanshinone with ophiopogonin D induced pharmacokinetic interaction prolonging the systemic exposure and improving metabolic stability of cryptotanshinone. The Caco-2 cells were employed to evaluate the transport of cryptotanshinone, and the metabolic stability was studied in the rat liver microsomes.
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