Drug Discovery World

NOVEMBER 27, 2023

This article is sponsored by Revvity. For instance, the engineering of CHO cells, widely used protein expression system, for various metabolic pathways has resulted in improved expression levels of large molecule drugs and product quality 1,2. After engineering, stable clones are screened, identified, and characterised.

Production 147

Production Engineering Molecular Biology Drug Development 147

Chemical Biology and Drug Design

DECEMBER 6, 2023

However, the pharmacodynamic mechanism and molecular target of SP-FC in the treatment of HS are still unclear. Therefore, this study is intended to explore the mechanism and target of SP-FC in the treatment of HS through network pharmacology combined with in vitro cell and molecular biology experiments.

Molecular Biology 100

Molecular Biology Protein Expression Treatment Regulations 100

Drug Target Review

MARCH 15, 2024

Efforts have focused on Chinese hamster ovary (CHO) cell line improvements since it is a commonly used host for the expression of therapeutic proteins. This article will focus on a novel transposon system for stable clone development with low variation. References Mistry RK, Kelsall E, Sou SN, et al.

Engineering 105

Engineering Molecular Biology Protein Expression Medical Schools 105