Chemical Biology and Drug Design

SEPTEMBER 6, 2023

Matrine inhibits TNBC cell proliferation, migration and invasion, promotes apoptosis, and suppresses tumor growth through down-regulation of HN1 expression. This study aimed to investigate the anti-tumor effect of matrine on the proliferation and apoptosis of TNBC cells based on HN1 regulation in vitro and in vivo.

Protein Expression 100

Protein Expression Regulations Treatment Drugs 100

Chemical Biology and Drug Design

FEBRUARY 19, 2024

However, the underlying molecular mechanism by which Icariin regulates osteogenic differentiation needs to be further revealed. The protein levels of osteogenic differentiation-related markers, sirtuin 1 (SIRT1), ubiquitin-specific protease 47 (USP47), and Wnt/β-catenin-related markers were determined using western blot.

Regulations 100

Regulations Protein Expression Research 100

Chemical Biology and Drug Design

JUNE 21, 2023

High expression of hsa-miR-503-5p and decreased expression of CTDSPL in LUAD contribute to cisplatin resistance and angiogenesis. Hsa-miR-503-5p negatively regulates CTDSPL, suggesting its potential as a target to overcome cisplatin resistance in LUAD.

Regulations 100

Regulations Protein Expression Bioinformatics Drugs 100

Chemical Biology and Drug Design

SEPTEMBER 24, 2023

The mRNA or protein expressions of examined genes in microglia and brain tissues were detected by quantitative real-time polymerase chain reaction or western blot. JAS reduces IS injury by regulating microglia polarization via PASK-EEF1A1 axis. PASK overexpression reversed the effects of JAS on microglia.

Regulations 100

Regulations Protein Expression Treatment Research 100

Chemical Biology and Drug Design

MARCH 5, 2024

Curcumin modulates the gene and protein expression levels of ferroptosis mediators via JNK signaling. Ferroptosis, a new form of regulated cell death, plays a vital role in the pathogenesis and therapy of cancers.

Protein Expression 100

Protein Expression Regulations Therapies Treatment 100

Chemical Biology and Drug Design

FEBRUARY 15, 2024

This study aimed to explore the mechanism through which prostaglandin E2 (PGE2) affects DE inflammation by regulating Th17. RT-qPCR and western blotting were used to test the mRNA and protein expression levels of IL-17 and retinoid-related orphan receptor-γt (RORγt). PGE2 was highly expressed in the DE mouse model.

Disease 100

Disease Protein Expression Regulations Treatment 100

Chemical Biology and Drug Design

MARCH 4, 2024

Real-time fluorescence quantitative PCR was used to detect the expression of miR-181a-3p. The expressions of SHQ1, activating transcription factor 6 (ATF6) and glucose regulated protein 78 (GRP78) were detected by western blot. β-Sitosterol effectively suppressed A549/anlotinib cell proliferation and promoted apoptosis.

Protein Expression 100

Protein Expression Regulations Treatment Drugs 100