Chemical Biology and Drug Design

MARCH 5, 2024

Curcumin modulates the gene and protein expression levels of ferroptosis mediators via JNK signaling. Ferroptosis, a new form of regulated cell death, plays a vital role in the pathogenesis and therapy of cancers.

Protein Expression 100

Protein Expression Regulations Therapies Treatment 100

Chemical Biology and Drug Design

AUGUST 2, 2023

Linagliptin administered to the type 1 diabetic mouse heart significantly reduced the expression levels of the total and cleaved forms of ATF6, ATF4, and p-JNK, caspase 3. According to ELISA findings, TUDCA was more effective in reducing NOX 1 and MDA levels than linagliptin.

Protein Expression 100

Protein Expression Therapies Treatment Research 100

Chemical Biology and Drug Design

MARCH 5, 2024

In addition, western blot analysis showed that CA-COS inhibits the protein expression of iNOS and nuclear factor kappa B (NF-kB), including p50 and p65, and mitogen-activated protein kinase (MAPK) signaling pathways.

Protein Expression 100

Protein Expression Therapies Production Disease 100

Codon

APRIL 9, 2023

” — Harold Morowitz 🔥 Ten Amazing Things (that happened this week…) A CAR-T therapy was tested in 27 children with neuroblastomas. AI + Bio *Transfer learning for cross-context prediction of protein expression from 5’UTR sequence. Molecular Therapy. Gene Therapy. McGrady N.R.

Therapies 52

Therapies RNA Engineering Vaccine 52

Alta Sciences

APRIL 17, 2024

In this blog article, we review some of these areas of investigation where Altasciences has robust expertise and solution offerings. According to a 2022 article published in Molecular Psychiatry, treatment resistance affects 20 to 60% of patients with psychiatric disorders.

Drug Development 52

Drug Development Treatment FDA Approval Therapies 52

Drug Target Review

MARCH 15, 2024

Efforts have focused on Chinese hamster ovary (CHO) cell line improvements since it is a commonly used host for the expression of therapeutic proteins. This article will focus on a novel transposon system for stable clone development with low variation. Cell Gene Therapy Insights 2017; 3(2), 131-158, 10.18609/cgti.2017.014.

Engineering 105

Engineering Molecular Biology Protein Expression Medical Schools 105

The Anticancer Fund

SEPTEMBER 29, 2021

Being listed is no endorsement of the results and conclusions of the article. All articles need to be critically assessed and viewed in their broader research context. Data from patients in the clinical trial showed decreased HER2 total protein expression and phosphorylation of AKT and S6 proteins in tumours.

Clinical Trials 40

Clinical Trials Drugs Trials Protein Expression 40