Chemical Biology and Drug Design

SEPTEMBER 25, 2023

Vinp treatment promotes Wnt proteins to connect the receptors complex on the cell membrane (consisting of FZD and LRP5/6), and then β-catenin is subsequently dissociated from the complex and translocated to the nucleus, activating transcription of downstream target genes. The mechanism diagram of Vinp on PD.

Disease 100

Disease Protein Expression Treatment Research 100

Chemical Biology and Drug Design

SEPTEMBER 24, 2023

This finding provides new ideas for the development of drug targets for the treatment of ischemic stroke. This research is powered to probe whether the molecular mechanism of JAS for IS treatment is coupled with microglia polarization. The polarization of microglia affects IS process.

Regulations 100

Regulations Protein Expression Treatment Research 100

Chemical Biology and Drug Design

AUGUST 9, 2023

A label-free proteomics technology was employed to investigate alterations in protein expression in LoVo cells treated with plumbagin. The LC-MS/MS proteomics assay revealed 78 proteins that were differentially expressed upon treatment with plumbagin.

Bioinformatics 100

Bioinformatics Protein Expression Treatment Research 100

Chemical Biology and Drug Design

MARCH 4, 2024

Abstract Anlotinib is used for the treatment of advanced non-small cell lung cancer; however, the emergence of drug resistance limits its clinical application. The expression of miR-181a-3p was inhibited; however, SHQ1 expression was increased by β-sitosterol treatment of A549/anlotinib cells.

Protein Expression 100

Protein Expression Regulations Treatment Drugs 100

Chemical Biology and Drug Design

AUGUST 23, 2023

The protein expressions were detected via western blot. The THS showed increased inflammation response proteins, mitochondria-dependent apoptosis proteins, and had a compensation effect on the Akt pathway. Ligustrazine at doses of 100 and 1000 μg/mL was administrated in Kupffer cells isolated from THS rats.

Protein Expression 100

Protein Expression Protein Production Production Treatment 100

Chemical Biology and Drug Design

AUGUST 21, 2023

Further, the study detected the effect of SA on cell apoptosis, lipid peroxidation, Fe 2+ level, and ferroptosis-related proteins expression. Finally, the effect of HMGB1 expression on SA in H/R stimulation was studied. Such effects of SA on H/R-induced cells were rescued by HMGB1 overexpression.

Protein Expression 100

Protein Expression Treatment Research 100

Chemical Biology and Drug Design

DECEMBER 6, 2023

However, the pharmacodynamic mechanism and molecular target of SP-FC in the treatment of HS are still unclear. Therefore, this study is intended to explore the mechanism and target of SP-FC in the treatment of HS through network pharmacology combined with in vitro cell and molecular biology experiments.

Molecular Biology 100

Molecular Biology Protein Expression Treatment Regulations 100

Chemical Biology and Drug Design

SEPTEMBER 21, 2023

Concretely, CPT-11 induced delayed diarrhea rat model and intestinal epithelial cell (IEC)-6 cell injury model with Baicalein treatment as needed. Colonic pathological changes were analyzed by hematoxylin–eosin staining, and inflammatory factor expressions in serum were determined by enzyme-linked immunosorbent assay.

Protein Expression 100

Protein Expression Treatment Research 100

Chemical Biology and Drug Design

DECEMBER 8, 2023

ELANE knockdown offset CAMP silencing-mediated inhibition of viability and promotion of inflammatory factors and pyroptosis-related protein expression in LPS/ATP/BoNT/A-treated rat DRG neurons. Conclusively, BoNT/A alleviates rat DRG neuron pyroptosis during PHN by upregulating CAMP to inhibit ELANE.

Protein Expression 100

Protein Expression Treatment Research 100

The Pharma Data

JANUARY 15, 2021

for the treatment of adult patients with locally advanced or metastatic HER2 positive gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen. .–(BUSINESS WIRE) January 15, 2021 — Daiichi Sankyo Company, Ltd. In the U.S., Sammons Cancer Center and the W.W. Caruth, Jr.

Treatment 52

Treatment Trials Disease Therapies 52

The Anticancer Fund

SEPTEMBER 29, 2021

Being listed is no endorsement of the results and conclusions of the article. All articles need to be critically assessed and viewed in their broader research context. This drug combination is rationally designed to target multiple escape mechanisms by which refractory disease evades treatment.

Clinical Trials 40

Clinical Trials Drugs Trials Protein Expression 40

Alta Sciences

APRIL 17, 2024

Five Promising Treatment Areas in Early-Phase Drug Development in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drug development is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues.

Drug Development 52

Drug Development Treatment FDA Approval Drugs 52

Codon

APRIL 9, 2023

Of those, 17 children responded to the treatment, and the 3-year overall survival rate was 60 percent. AI + Bio *Transfer learning for cross-context prediction of protein expression from 5’UTR sequence. The CAR-T cells were detectable in 26 out of 27 children after 30 months. Subscribe to learn more.

Therapies 52

Therapies RNA Engineering Vaccine 52

Broad Institute

SEPTEMBER 5, 2024

In recent years, increasingly sensitive mass spectrometers have paved the way for enormous progress: scientists are now able to detect and analyze nearly all proteins expressed in a sample, including ones present only in miniscule amounts. It's a matter of how much of that protein is present relative to its environment.

Disease 66

Disease Protein Expression Engineering Treatment 66