Chemical Biology and Drug Design

AUGUST 23, 2023

We hypothesized that ligustrazine could protect liver by decreasing the inflammation response, protein production, and apoptosis in THS rats. The protein expressions were detected via western blot. It also decreases the platelets' bioactivity and reduces reactive oxygen species formation.

Protein Expression 100

Protein Expression Protein Production Treatment Production 100

Drug Target Review

MARCH 15, 2024

Advancements in cell line development (CLD), including screening and selection of final clones, scale up, automation and digitalisation have enabled precision and enhanced productivity. Efforts have focused on Chinese hamster ovary (CHO) cell line improvements since it is a commonly used host for the expression of therapeutic proteins.

Engineering 105

Engineering Molecular Biology Protein Expression Medical Schools 105

Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

Production 40

Production FDA Therapies Biochemical Assays 40

Drug Target Review

JULY 5, 2023

A good introduction to the use of CHO cells for biotherapeutics production can be found in an article commemorating the 20th anniversary of the approval of a product produced using CHO cells. 1 Another critical component in this first step is the selectable marker that will be inserted into the genome along with the GOIs.

Engineering 105

Engineering DNA Laboratories Production 105

PLOS: DNA Science

JUNE 13, 2024

The most compelling evidence for the origin lies in the RNA genome sequence similarities between RaTG13 and SARS-CoV-2 – specifically, a part that encodes the “furin binding site” of the spike protein with which the virus adheres to host cells. Coincidence? I’ve never thought so.

Virus 52

Virus RNA DNA Science 52

Drug Target Review

DECEMBER 10, 2024

Protein manufacturing plays a vital role in advancing medicine, enabling the creation of vaccines, therapeutic proteins, and other bioproducts that address global health challenges. As the industry evolves, there is a growing need for innovative solutions to make these processes more efficient, accessible, and sustainable.

Protein Production 98

Protein Production Production Engineering Vaccine 98