Agency IQ

MAY 31, 2024

and national regulators. Fill out the form to read the full article. Given the expansive and complex European life sciences regulatory landscape, we’ll be including updates from key E.U.

Regulations 59

Regulations Science 59

Agency IQ

JULY 8, 2024

BY SEBASTIAN GODOY, MPH , KIRSTEN MESSMER, PHD, RAC , COREY JASEPH, MS, RAC , KARI OAKES In this recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more.

Regulations 59

Regulations Science 59

Agency IQ

JUNE 21, 2024

BY KIRSTEN MESSMER, PHD, RAC This week, the newly finalized Variations Regulation was published in the Official Journal of the E.U. An updated guideline implementing the changes from the new regulation is now open for public consultation until August 23, 2024. Fill out the form to read the full article.

Regulations 59

Regulations Production 59

Agency IQ

MARCH 29, 2024

BY WALKER LIVINGSTON, ESQ The White House Office of Information and Regulatory Affairs has cleared a final rule that will implement the first national drinking water regulations for per- and polyfluoroalkyl substances. The rule, once released, will set the tone for future PFAS regulation in the U.S.

Regulations 59

Regulations 59

Chemical Biology and Drug Design

JANUARY 7, 2024

The tumour killing effects of chrysophanol possible owing to its targeted regulation on mTOR. Screening by GEO software indicated that the mTOR signalling pathway is possibly regulated by chrysophanol. The beneficial effects of chrysophanol may be attribute to the targeted regulation of mTOR.

Regulations 100

Regulations Treatment Research 100

Agency IQ

JULY 8, 2024

Board of Governors, holding that the law allows litigants to challenge agency regulations within six years of being harmed by those regulations, rather than six years from the time the agency finalized the regulations. Fill out the form to read the full article.

Regulations 59

Regulations 59

Agency IQ

JULY 22, 2024

BY WALKER LIVINGSTON, ESQ On July 5, 2024, the EPA published its Spring 2024 Unified Agenda, which reveals what regulations the agency is planning on releasing by the end of the year and beyond. Fill out the form to read the full article.

Regulations 59

Regulations 59

Agency IQ

AUGUST 2, 2024

By Sebastian Godoy, MPH , Kirsten Messmer, PhD, RAC, Corey Jaseph, MS, RAC , Kari Oakes In this recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more.

Regulations 59

Regulations 59

Agency IQ

JULY 12, 2024

BY ALEXANDER GAFFNEY, MS, RAC The FDA on Friday unveiled its much-anticipated Spring 2024 Unified Agenda, a document outlining the regulations the agency plans to release in 2024 and beyond. Fill out the form to read the full article.

Regulations 59

Regulations FDA 59

Agency IQ

JANUARY 12, 2024

To kick off 2024, the British device regulator offered its medical device and IVD plans for this year and next, promising public action on the post-market surveillance regulation by mid-2024 and on the core regulations in late 2024 or early 2025. Fill out the form to read the full article.

Regulations 59

Regulations Marketing 59

Drug Patent Watch

DECEMBER 11, 2024

In this article, we will delve into the key criteria for selecting a CDMO, highlighting the essential factors to consider and the importance of effective communication and cultural fit. Your Drugs Development Stage The stage of your drug development is a critical factor in selecting a CDMO.

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Pharmaceutical Companies Compliance Pharmaceuticals Drug Development 98

Chemical Biology and Drug Design

NOVEMBER 1, 2023

Kaempferol exerted antioxidant effects in AR-DOR by inhibiting Hsp90 to up-regulate Nrf2. The results showed that HSP90 was predicted to have high affinity with kaempferol, and its expression was inhibited by kaempferol, while the expression of NRF2, the target of HSP90, was up-regulated by kaempferol.

Regulations 100

Regulations Treatment Clinical Research Research 100

FDA Law Blog: Biosimilars

OCTOBER 16, 2023

Gonzalez — The Wall Street Journal (WSJ) recently published a series of articles as part of its special report “What’s Ahead for Artificial Intelligence.” Three of these articles focus on medical applications of Artificial Intelligence and Machine Learning (AI/ML) and explore FDA’s role in regulating such products.

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Regulations FDA Production Disease 119

Agency IQ

APRIL 12, 2024

BY LAURA DIANGELO, MPH In the past few years, regulators and researchers have shown increased interest in leveraging decentralized trial methods – especially following the pandemic. In this article, AgencyIQ explores the current regulatory state of decentralized trials and what’s likely coming next.

Regulations 59

Regulations Trials Clinical Trials Research 59

Agency IQ

OCTOBER 27, 2023

In this new recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more. and national regulators.

Regulations 59

Regulations Science 59

Chemical Biology and Drug Design

FEBRUARY 19, 2024

However, the underlying molecular mechanism by which Icariin regulates osteogenic differentiation needs to be further revealed. The regulation of USP47 on SIRT1 was confirmed by ubiquitination detection and co-immunoprecipitation analysis. The viability of BMSCs was assessed by cell counting kit 8 assay.

Regulations 100

Regulations Protein Expression Research 100

Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p negatively regulates CTDSPL, suggesting its potential as a target to overcome cisplatin resistance in LUAD. Hsa-miR-503-5p bound to CTDSPL gene and promoted cisplatin resistance and malignant progression of LUAD cells by negatively regulating CTDSPL.

Regulations 100

Regulations Protein Expression Bioinformatics Drugs 100

Agency IQ

DECEMBER 1, 2023

In this new recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more. and national regulators.

Regulations 59

Regulations Science 59

Agency IQ

MARCH 29, 2024

and national regulators. Fill out the form to read the full article. Given the expansive and complex European life sciences regulatory landscape, we’ll be including updates from key E.U. The goal: to allow regulatory professionals to better anticipate and prepare for upcoming events and catalysts.

Regulations 59

Regulations Science 59

Agency IQ

MARCH 1, 2024

and national regulators. Fill out the form to read the full article. Given the expansive and complex European life sciences regulatory landscape, we’ll be including updates from key E.U. The goal: to allow regulatory professionals to better anticipate and prepare for upcoming events and catalysts.

Regulations 59

Regulations Science 59

Chemical Biology and Drug Design

JANUARY 24, 2024

From result of network analysis, the possible underlying mechanism of YH complex was closely related with the “regulation of hair cycle” and “apoptosis signaling pathway.” In summary, YH complex regulated hair development cycle by inhibiting the androgenic-apoptotic axis in AGA.

Regulations 100

Regulations Treatment Research 100

Agency IQ

APRIL 12, 2024

BY WALKER LIVINGSTON, ESQ The EPA has released its much-awaited National Primary Drinking Water Regulation for six different PFAS. Fill out the form to read the full article. There are a wide variety of definitions for PFAS and consistent debate on which definition is most applicable.

Regulations 59

Regulations Compliance 59

Chemical Biology and Drug Design

SEPTEMBER 24, 2023

JAS reduces IS injury by regulating microglia polarization via PASK-EEF1A1 axis. OGD/R treatment decreased microglial viability as well as expressions of CD206, Arg-1, IL-10, and EEF1A1, yet increased cytotoxicity and levels of IL-1β, CD32, TNF-α, PASK, p-EEF1A1, and p-EEF1A1/EEF1A1, which was reversed by JAS.

Regulations 100

Regulations Protein Expression Treatment Research 100

Agency IQ

AUGUST 30, 2024

By Sebastian Godoy, MPH , Corey Jaseph, MS, RAC , Kari Oakes In this recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations and comment periods.

Regulations 52

Regulations 52

Chemical Biology and Drug Design

JANUARY 23, 2024

Matrine inhibits the growth and metastasis of hepatocellular carcinoma by regulating the ELAVL1/RBM3-mediated Wnt/β-catenin signaling pathway. Moreover, ELAVL1 might bind with RBM3 to positively regulate the stability of RBM3 mRNA. Nevertheless, the anti-tumor molecular mechanism of Martine in HCC is still not fully revealed.

Regulations 100

Regulations RNA Treatment Research 100

Chemical Biology and Drug Design

SEPTEMBER 6, 2023

Matrine inhibits TNBC cell proliferation, migration and invasion, promotes apoptosis, and suppresses tumor growth through down-regulation of HN1 expression. This study aimed to investigate the anti-tumor effect of matrine on the proliferation and apoptosis of TNBC cells based on HN1 regulation in vitro and in vivo.

Protein Expression 100

Protein Expression Regulations Treatment Drugs 100

Chemical Biology and Drug Design

DECEMBER 13, 2024

Tectorigenin could reduce the expression levels of inflammatory cytokines in both DBV-infected THP-1 cells and plasma samples of IFNAR / mice infected with DBV. ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is a severe emerging infectious disease caused by Dabie bandavirus (DBV).

Regulations 100

Regulations Disease Research 100

Agency IQ

MAY 3, 2024

Fill out the form to read the full article.

Regulations 52

Regulations 52

Chemical Biology and Drug Design

MARCH 8, 2024

Circ_0139658 is directly bound to miR-653-5p to regulate YY1 expression. Brucine suppressed the proliferation, migration, and invasion of RA-FLSs, and alleviated inflammation by reducing the release of pro-inflammatory factors and macrophage M1 polarization. RA-FLSs showed increased circ_0139658 and YY1 levels and decreased miR-653-5p levels.

Regulations 100

Regulations RNA Treatment Research 100

Agency IQ

MAY 28, 2024

BY COREY JASEPH, MS, RAC The British medical device regulator just issued its promised framework on international recognition. Fill out the form to read the full article.

International 52

International Regulations Marketing 52

Drug Patent Watch

FEBRUARY 26, 2025

In this article, we'll delve into the world of drafting drug patent applications for biologic drugs. However, the patentability of biologics is governed by specific laws and regulations, such as the Biologics Price Competition and Innovation Act (BPCIA). Read the full article here: [link]

Drugs 59

Drugs Government Regulations Compliance 59

Agency IQ

FEBRUARY 23, 2024

Under Section 112(r) of the Clean Air Act, the EPA must publish regulations and guidance regarding chemical accident protection at facilities nationwide. Fill out the form to read the full article.

Regulations 59

Regulations 59

Chemical Biology and Drug Design

JANUARY 24, 2024

Baicalin alleviates OGD/R-induced SK-N-SH cell apoptosis, inflammation, and ferroptosis in vitro, and brain injury in MCAO mice in vivo, via the regulation of miR-556-3p/ACSL4 pathway. In conclusion, BCL alleviated OGD/R-induced SK-N-SH cell injury and relieved brain injury in MCAO mice by regulating miR-556-3p/ACSL4 axis.

Regulations 100

Regulations RNA Treatment Research 100

Agency IQ

MARCH 15, 2024

The newly released draft regulations, statement of reason and regulatory impact assessment all point to the wide-reaching implications that the rule will have for a variety of industries across the state. Fill out the form to read the full article.

Regulations 59

Regulations 59

Agency IQ

NOVEMBER 10, 2023

The European Commission has proposed a regulation to revise the fees regulation governing the cost of compensating the European Medicines Agency (EMA) for its regulatory activities, with the aim of streamlining the fee structure and increasing fees in line with the cost of services and inflation.

Regulations 59

Regulations Government 59

Chemical Biology and Drug Design

FEBRUARY 3, 2025

ABSTRACT PTP-PEST (also known as PTPN12) regulates cellular signaling and transduction pathways by dephosphorylating its substrate. The invitro biochemical assays validated that J1-65 inhibits PTP-PEST activity competitively and the inhibitor binding stabilizes the protein-ligand complex.

Small Molecule 100

Small Molecule Biochemical Assays Regulations Drugs 100

Chemical Biology and Drug Design

MARCH 14, 2023

EVO regulates ovarian cancer progression through the NEAT1-miR-152-3p-CDK19 axis, which further advances the possibility of EVO as a therapeutic drug for ovarian cancer. EVO dose-dependently attenuated cell viability, induced G2/M phase arrest, and apoptosis in ovarian cancer cells.

Regulations 100

Regulations Bioinformatics Drugs Research 100