Chemical Biology and Drug Design

JULY 13, 2023

Coptisine inhibits the malignancy of BC cells via regulating XPO1. In summary, COP represses the malignant biological behaviors of bladder carcinoma cells and regulates XPO1 expression, which is promising to be a complementary drug for bladder carcinoma treatment.

Regulations 100

Regulations Bioinformatics Treatment Drugs 100

Chemical Biology and Drug Design

FEBRUARY 19, 2024

However, the underlying molecular mechanism by which Icariin regulates osteogenic differentiation needs to be further revealed. The regulation of USP47 on SIRT1 was confirmed by ubiquitination detection and co-immunoprecipitation analysis. The viability of BMSCs was assessed by cell counting kit 8 assay.

Regulations 100

Regulations Protein Expression Research 100

Agency IQ

MAY 31, 2024

and national regulators. Fill out the form to read the full article. Given the expansive and complex European life sciences regulatory landscape, we’ll be including updates from key E.U.

Regulations 59

Regulations Science 59

Agency IQ

JULY 8, 2024

BY SEBASTIAN GODOY, MPH , KIRSTEN MESSMER, PHD, RAC , COREY JASEPH, MS, RAC , KARI OAKES In this recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more.

Regulations 59

Regulations Science 59

Agency IQ

MARCH 29, 2024

and national regulators. Fill out the form to read the full article. Given the expansive and complex European life sciences regulatory landscape, we’ll be including updates from key E.U. The goal: to allow regulatory professionals to better anticipate and prepare for upcoming events and catalysts.

Regulations 59

Regulations Science 59

Agency IQ

MARCH 1, 2024

and national regulators. Fill out the form to read the full article. Given the expansive and complex European life sciences regulatory landscape, we’ll be including updates from key E.U. The goal: to allow regulatory professionals to better anticipate and prepare for upcoming events and catalysts.

Regulations 59

Regulations Science 59

Agency IQ

JUNE 21, 2024

BY KIRSTEN MESSMER, PHD, RAC This week, the newly finalized Variations Regulation was published in the Official Journal of the E.U. An updated guideline implementing the changes from the new regulation is now open for public consultation until August 23, 2024. Fill out the form to read the full article.

Regulations 59

Regulations Production 59

Agency IQ

AUGUST 9, 2024

Specifically, the EU executive’s proposal seeks to harmonize the POPs Regulation, carving out exclusions for mechanical separators in blood collection tubes, triacetyl cellulose film in polarizers, and photographic paper, among other exempted articles containing UV-328. Fill out the form to read the full article.

Regulations 59

Regulations 59

Chemical Biology and Drug Design

JANUARY 24, 2024

From result of network analysis, the possible underlying mechanism of YH complex was closely related with the “regulation of hair cycle” and “apoptosis signaling pathway.” In summary, YH complex regulated hair development cycle by inhibiting the androgenic-apoptotic axis in AGA.

Regulations 100

Regulations Treatment Research 100

Agency IQ

JULY 8, 2024

Board of Governors, holding that the law allows litigants to challenge agency regulations within six years of being harmed by those regulations, rather than six years from the time the agency finalized the regulations. Fill out the form to read the full article.

Regulations 59

Regulations 59

Chemical Biology and Drug Design

JANUARY 23, 2024

Matrine inhibits the growth and metastasis of hepatocellular carcinoma by regulating the ELAVL1/RBM3-mediated Wnt/β-catenin signaling pathway. Moreover, ELAVL1 might bind with RBM3 to positively regulate the stability of RBM3 mRNA. Nevertheless, the anti-tumor molecular mechanism of Martine in HCC is still not fully revealed.

Regulations 100

Regulations RNA Treatment Research 100

Agency IQ

JULY 22, 2024

BY WALKER LIVINGSTON, ESQ On July 5, 2024, the EPA published its Spring 2024 Unified Agenda, which reveals what regulations the agency is planning on releasing by the end of the year and beyond. Fill out the form to read the full article.

Regulations 59

Regulations 59

Agency IQ

AUGUST 2, 2024

By Sebastian Godoy, MPH , Kirsten Messmer, PhD, RAC, Corey Jaseph, MS, RAC , Kari Oakes In this recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more.

Regulations 59

Regulations 59

Chemical Biology and Drug Design

MARCH 8, 2024

Circ_0139658 is directly bound to miR-653-5p to regulate YY1 expression. Brucine suppressed the proliferation, migration, and invasion of RA-FLSs, and alleviated inflammation by reducing the release of pro-inflammatory factors and macrophage M1 polarization. RA-FLSs showed increased circ_0139658 and YY1 levels and decreased miR-653-5p levels.

Regulations 100

Regulations RNA Treatment Research 100

Agency IQ

JULY 12, 2024

BY ALEXANDER GAFFNEY, MS, RAC The FDA on Friday unveiled its much-anticipated Spring 2024 Unified Agenda, a document outlining the regulations the agency plans to release in 2024 and beyond. Fill out the form to read the full article.

Regulations 59

Regulations FDA 59

Chemical Biology and Drug Design

NOVEMBER 1, 2023

Kaempferol exerted antioxidant effects in AR-DOR by inhibiting Hsp90 to up-regulate Nrf2. The results showed that HSP90 was predicted to have high affinity with kaempferol, and its expression was inhibited by kaempferol, while the expression of NRF2, the target of HSP90, was up-regulated by kaempferol.

Regulations 100

Regulations Treatment Clinical Research Research 100

Agency IQ

FEBRUARY 23, 2024

Under Section 112(r) of the Clean Air Act, the EPA must publish regulations and guidance regarding chemical accident protection at facilities nationwide. Fill out the form to read the full article.

Regulations 59

Regulations 59

Chemical Biology and Drug Design

JANUARY 24, 2024

Baicalin alleviates OGD/R-induced SK-N-SH cell apoptosis, inflammation, and ferroptosis in vitro, and brain injury in MCAO mice in vivo, via the regulation of miR-556-3p/ACSL4 pathway. In conclusion, BCL alleviated OGD/R-induced SK-N-SH cell injury and relieved brain injury in MCAO mice by regulating miR-556-3p/ACSL4 axis.

Regulations 100

Regulations RNA Treatment Research 100

FDA Law Blog: Biosimilars

OCTOBER 16, 2023

Gonzalez — The Wall Street Journal (WSJ) recently published a series of articles as part of its special report “What’s Ahead for Artificial Intelligence.” Three of these articles focus on medical applications of Artificial Intelligence and Machine Learning (AI/ML) and explore FDA’s role in regulating such products.

Regulations 119

Regulations FDA Production Disease 119

Agency IQ

MARCH 15, 2024

The newly released draft regulations, statement of reason and regulatory impact assessment all point to the wide-reaching implications that the rule will have for a variety of industries across the state. Fill out the form to read the full article.

Regulations 59

Regulations 59

Agency IQ

APRIL 12, 2024

BY LAURA DIANGELO, MPH In the past few years, regulators and researchers have shown increased interest in leveraging decentralized trial methods – especially following the pandemic. In this article, AgencyIQ explores the current regulatory state of decentralized trials and what’s likely coming next.

Regulations 59

Regulations Trials Clinical Trials Research 59

Agency IQ

OCTOBER 27, 2023

In this new recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more. and national regulators.

Regulations 59

Regulations Science 59

Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p negatively regulates CTDSPL, suggesting its potential as a target to overcome cisplatin resistance in LUAD. Hsa-miR-503-5p bound to CTDSPL gene and promoted cisplatin resistance and malignant progression of LUAD cells by negatively regulating CTDSPL.

Regulations 100

Regulations Protein Expression Bioinformatics Drugs 100

Agency IQ

DECEMBER 1, 2023

In this new recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more. and national regulators.

Regulations 59

Regulations Science 59

Chemical Biology and Drug Design

MARCH 8, 2024

Besides, SSD (4 μM) treatment could significantly up-regulate the cell viability and marker expression of PP-induced astrocytes. PP treatment (1 mM) induced cell injury by significantly reducing the viability of astrocytes and expression of cellular markers. SSD treatment (4 μM) had no toxicity to astrocytes.

Regulations 100

Regulations Treatment Research 100

Chemical Biology and Drug Design

JANUARY 4, 2024

Furthermore, AS-IV performed a beneficial anti-cancer effect by regulating the circ_0001615/miR-873-5p/LASP1 network in the CRC. Applying astragaloside IV (AS-IV) might repress the expression of circ_0001615 in colorectal cancer (CRC) cell lines.

Regulations 100

Regulations RNA Treatment Research 100

Agency IQ

APRIL 12, 2024

BY WALKER LIVINGSTON, ESQ The EPA has released its much-awaited National Primary Drinking Water Regulation for six different PFAS. Fill out the form to read the full article. There are a wide variety of definitions for PFAS and consistent debate on which definition is most applicable.

Regulations 59

Regulations Compliance 59

Chemical Biology and Drug Design

SEPTEMBER 24, 2023

JAS reduces IS injury by regulating microglia polarization via PASK-EEF1A1 axis. OGD/R treatment decreased microglial viability as well as expressions of CD206, Arg-1, IL-10, and EEF1A1, yet increased cytotoxicity and levels of IL-1β, CD32, TNF-α, PASK, p-EEF1A1, and p-EEF1A1/EEF1A1, which was reversed by JAS.

Regulations 100

Regulations Protein Expression Treatment Research 100

Chemical Biology and Drug Design

SEPTEMBER 6, 2023

Matrine inhibits TNBC cell proliferation, migration and invasion, promotes apoptosis, and suppresses tumor growth through down-regulation of HN1 expression. This study aimed to investigate the anti-tumor effect of matrine on the proliferation and apoptosis of TNBC cells based on HN1 regulation in vitro and in vivo.

Protein Expression 100

Protein Expression Regulations Treatment Drugs 100

Agency IQ

AUGUST 30, 2024

By Sebastian Godoy, MPH , Corey Jaseph, MS, RAC , Kari Oakes In this recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations and comment periods.

Regulations 52

Regulations 52

Agency IQ

MAY 3, 2024

Fill out the form to read the full article.

Regulations 52

Regulations 52

Agency IQ

MAY 28, 2024

BY COREY JASEPH, MS, RAC The British medical device regulator just issued its promised framework on international recognition. Fill out the form to read the full article.

International 52

International Regulations Marketing 52

Chemical Biology and Drug Design

FEBRUARY 22, 2024

However, the role and mechanism of TMEM97 in regulating 5-FU resistance in CRC cells remains unclear. In conclusion, TMEM97 knockdown inhibited 5-FU resistance in CRC by regulating EMT and ABC transporter expression via inactivating the Akt/mTOR pathway. Transmembrane protein 97 (TMEM97) functions as an oncogene in CRC.

Regulations 100

Regulations Research 100

Agency IQ

NOVEMBER 10, 2023

The European Commission has proposed a regulation to revise the fees regulation governing the cost of compensating the European Medicines Agency (EMA) for its regulatory activities, with the aim of streamlining the fee structure and increasing fees in line with the cost of services and inflation.

Regulations 59

Regulations Government 59

Chemical Biology and Drug Design

JANUARY 4, 2024

Curcumin activates ATF6-regulated endoplasmic reticulum (ER) stress, promotes ATF6 nuclear translocation, activates Chop/Bax/Bcl-2/Caspase-3 apoptosis pathway, and promotes apoptosis of CRC cells. Abstract Colorectal cancer (CRC) is the main cause of cancer-associated death.

Regulations 189

Regulations Treatment Research 189

SCIENMAG: Medicine & Health

FEBRUARY 26, 2024

Another mystery is the regulation of cytochrome P450 enzymes (CYPs) in the central nervous system. DCM is the leading cause of heart failure in patients with chronic diabetes. However, the underlying mechanisms of DCM are poorly understood, and treatment options are limited.

Disease 75

Disease Pharmaceuticals Regulations Treatment 75

Chemical Biology and Drug Design

JANUARY 5, 2024

Moreover, matrine also could regulate PDK1 expression to suppress AML progression. Mechanistically, miR-495-3p/miR-543 directly targeted PDK1, and the inhibition impacts of miR-495-3p/miR-543 on AML progression could be rescued by PDK1 overexpression.

Regulations 100

Regulations Production Research 100