Science Daily: Pharmacology News

JUNE 27, 2023

In a pair of articles, they report that, in experiments with flakes of semiconductor materials -- each only a single layer of atoms thick -- they detected signatures of 'fractional quantum anomalous Hall' (FQAH) states. Scientists and engineers have announced a significant advancement in developing fault-tolerant qubits for quantum computing.

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Science Daily: Pharmacology News

SEPTEMBER 27, 2023

A new article has analyzed another understudied behavior in baleen (filter-feeding) whales such as humpback whales in different populations across the northern and southern hemispheres. The research also emphasizes that the behavior was similar in different individuals, regardless of where in the world it occurred.

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Chemical Biology and Drug Design

MARCH 26, 2025

In this article, we present the synthesis of novel 3-phenyl-1-((1-aryl-1 H -1,2,3-triazol-5-yl)methyl)spiro[indoline-3,2-oxiran]-2-one derivatives by the regioselective reaction of sulfur ylides with 1,2,3-triazole-tethered isatins and their anticancer effects on hepatocellular carcinoma (HCC) cells HepG2 and HCCLM3.

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Research 100

Drug Discovery Today

DECEMBER 7, 2023

A team led by Research Professor Gintautas Tamulaitis from Vilnius University Life Sciences Center (VU LSC) revealed a novel protection mechanism in CRISPR-Cas antiviral defense system. The article “Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling” was published in the journal Science.

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Drug Target Review

DECEMBER 23, 2024

To explore these challenges further, we spoke with Cheng Wang, a postdoctoral researcher at the University at Buffalo. Wangs research focuses on developing mechanistic mathematical models to quantitatively characterise ADC-induced toxicities. This provides a strong starting point for new ADC development, Wang explained.

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Drug Patent Watch

DECEMBER 10, 2024

The pharmaceutical industry has undergone significant changes over the past decade, with a growing trend towards outsourcing key aspects of research, development, and manufacturing to third-party vendors. The Rise of Integrated CDMOs The global biotechnology and pharmaceutical services outsourcing market size was valued at $70.48

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Science Daily: Pharmacology News

AUGUST 28, 2023

A new article describes the 266 fossil species as one of the richest and most diverse groups of three-million-year-old fauna ever found in New Zealand. At least ten previously unknown species will be described and named in future research.

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Treatment Research 189

Chemical Biology and Drug Design

FEBRUARY 15, 2024

This article highlights the various structural features along with the structure–activity relationship (SAR) of nitrogen-containing heterocyclics that play a key role in binding at target sites for potential antidepressant action.

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Drugs Research 189

Drug Patent Watch

FEBRUARY 12, 2025

The generic drug development process involves several stages, from patent research to regulatory approvals. Here are a few: Thorough Patent Research : Conducting comprehensive patent research is critical to identifying potential patent challenges and developing a robust strategy to overcome them.

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Advarra

AUGUST 8, 2024

The EU AI Act’s implications extend into clinical research, where AI is increasingly utilized for tasks like medical image analysis, natural language process for endpoint analysis, and generating/analyzing data for synthetic control arms. Non-EU companies must comply with the AI Act if their AI systems are used in the EU market.

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Clinical Research Research Clinical Trials Compliance 98

Drug Patent Watch

FEBRUARY 11, 2025

The Dark Side of Innovation: How Companies Use Drug Patents to Block Competitors As we celebrate the breakthroughs in medical research and the development of life-saving treatments, it's essential to acknowledge the complex landscape of pharmaceutical innovation. Read the full article here What do you think?

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Drug Target Review

JANUARY 14, 2025

Operating a workflow, such as the one described in Figure 1, involves several key considerations that affect both the accuracy of results and the efficiency of the research process. Defining the research question A well-defined research question is the cornerstone of an effective scientific workflow in drug discovery.

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Drugs Protein Expression Science Research 69

Chemical Biology and Drug Design

DECEMBER 15, 2023

Given the substantial body of evidence supporting the neuroprotective potential of exendin-4 in various research models, this article is dedicated to exploring the promising role of exendin-4 as a therapeutic agent for the treatment and management of Alzheimer's disease and Parkinson's disease.

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Disease Therapies Treatment Research 189

Drug Patent Watch

DECEMBER 11, 2024

In this article, we will delve into the key criteria for selecting a CDMO, highlighting the essential factors to consider and the importance of effective communication and cultural fit. Your Drugs Development Stage The stage of your drug development is a critical factor in selecting a CDMO.

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Pharmaceutical Companies Compliance Pharmaceuticals Drug Development 98

Drug Target Review

DECEMBER 6, 2024

In drug discovery and biological research, the scientists workflow often follows a structured and iterative approach to ensure accuracy, reproducibility and scientific integrity. At the heart of any research is the scientific question. This acts as a safeguard against false positives and misinterpretation of the data.

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RNA Drugs Research Science 52

Drug Target Review

MARCH 24, 2025

Having previously drawn parallels with industry adoption of electronic lab notebooks in part 1 , this article expands on his vision for the future of the industry, sharing his forward-thinking ideas and practical recommendations. This breakthrough could fundamentally change how drugs are developed and tested.

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Clinical Trials Animal Testing Drugs Pharmacokinetics 59

KIF1A

FEBRUARY 10, 2024

Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. And just like it can be challenging to play a new game without knowing all the rules, one hurdle for gene therapy research and development has been a lack of a playbook.

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Therapies Clinical Trials FDA Disease 111

Quanticate

JULY 5, 2024

Good Clinical Practice (GCP) affects a variety of entities, including sponsors, contract research organisations (CROs), and investigator sites. In our article we look into the potential implications of E6(R3) for the future of clinical studies and how organisations can best prepare for these changes.

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Clinical Research Drug Development Treatment Research 111

Chemical Biology and Drug Design

JUNE 7, 2023

This article utilized template-based molecular docking of peptides and receptors to identify six highly valuable mutation sites. Subsequent amino acid multi-site mutations were conducted to establish a virtual polypeptide library.

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Treatment Research 177

Drug Patent Watch

OCTOBER 9, 2023

The article titled “Reviving an R&D Pipeline: A Step Change in the Phase II Success Rate” discusses Pfizer’s efforts to improve its research and development (R&D) productivity. The pharmaceutical industry… The post Reviving an R&D Pipeline appeared first on DrugPatentWatch - Make Better Decisions.

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KIF1A

APRIL 13, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. Read the Article See the Little SENDsations website The post #ScienceSaturday: April 13, 2024 appeared first on KIF1A.

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Disease Research Science 111

NIOSH Science Blog: Drugs

JUNE 5, 2024

This blog highlights select research and prevention efforts from the National Institute for Occupational Safety and Health (NIOSH) and NSC in this year’s focus areas of safety engagement; roadway safety; risk reduction; and slips, trips and falls. For each week of the month, the National Safety Council (NSC) identifies a theme to focus on.

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Research 112

Chemical Biology and Drug Design

MARCH 12, 2025

Therefore, it is an important target for antibacterial drug research. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis. Although many MurA inhibitors have been discovered, only fosfomycin is still used as a MurA inhibitor in clinical practice.

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Drug Research Research Drugs 100

Codon

OCTOBER 22, 2024

He suggests that peer review doesn’t “do the thing it’s supposed to do” — namely, “catch bad research and prevent it from being published,” so perhaps scientists would be better off uploading PDFs to the internet where review and oversight can happen post-publication.

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KIF1A

MARCH 16, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. Read the Article The post ScienceSaturday: March 16, 2024 appeared first on KIF1A.

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Disease Clinical Development Research Treatment 105

KIF1A

JANUARY 27, 2024

Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. This study also highlights the diversity of HSP types: across 18 patients, researchers identified 15 different spastic paraplegia subtypes.

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Drug Target Review

JANUARY 8, 2024

In this eBook, we explore how researchers identified two unique proteins within N. This article summarises their work to date, including a high-throughput fluorescence assay of guanine nucleotide hydrolysis for rapid But that’s not all.

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Drugs International Science Research 111

Drug Patent Watch

NOVEMBER 20, 2024

Generic drug development is a complex process that involves rigorous scientific research and regulatory assessments. This article delves into the scientific aspects of generic drug development, highlighting the key initiatives and resources… Source

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Drug Development Science Drugs FDA 98

Drug Patent Watch

MARCH 3, 2025

Breaking Down Barriers: The Power of Global Research Collaborations in Generic Drug Development As the world grapples with the complexities of healthcare, one thing is clear: the need for innovative solutions has never been more pressing. Read the full article here: [link] Share your thoughts in the comments below!

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The ChEMBL-og

OCTOBER 23, 2024

However, researchers also need to know how these molecules interact with their biological target – their bioactivity. This can be a roadblock for researchers who need that structural information to design effective drugs. > BCG Training More information can be found in the official EBI communications article. ->

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Small Molecule Drugs Research Science 117

Drug Patent Watch

FEBRUARY 26, 2025

In this article, we'll delve into the world of drafting drug patent applications for biologic drugs. Conduct thorough research : A thorough search of prior art and regulatory requirements is essential to identify novel and non-obvious features. Read the full article here: [link]

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Drug Target Review

DECEMBER 20, 2024

These twins simulate how a patients condition might evolve without treatment, enabling researchers to compare the real-world effects of an experimental therapy against predicted outcomes. He was a postdoctoral researcher in mathematics at the University of Waterloo. Aaron received his Ph.D.

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Clinical Trials Trials Pharmaceuticals Drug Development 128

Quanticate

AUGUST 2, 2024

By using Real-World Data (RWD) from various sources like electronic health records (EHRs), insurance claims, and digital health tools, researchers can gather valuable insights into how drugs work in a wide range of populations.

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Drug Development Clinical Trials Drugs Trials 104

KIF1A

SEPTEMBER 30, 2023

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research In the rare disease space, a common and straightforward question is: How rare is the disease? What’s a pre-print? What’s a pre-print?

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Chemical Biology and Drug Design

APRIL 3, 2024

This article presents an in-depth examination of the interplay between autophagy and proteostasis, highlighting how these processes cooperatively contribute to cellular homeostasis and prevent pathogenic protein aggregate accumulation.

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Drug Patent Watch

JANUARY 15, 2025

Identifying drug patents is crucial for various stakeholders, including researchers, legal professionals, and business strategists. This article explores the limitations of Google Patents in this context and suggests alternative approaches. Implications for Pharmaceutical Stakeholders 1.

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Drugs Pharmaceuticals Engineering Research 59

Drug Patent Watch

JANUARY 21, 2025

Key Takeaways: Identify and prioritize patent opportunities based on market research and competitor analysis Leverage data and analytics to inform decision-making and maximize return on investment Stay up-to-date on the latest patent trends and developments to stay ahead of the curve What's your approach to drug patent portfolio management?

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