Biochemical Assays Cell Based Assays Disease 
Molecular Design
DECEMBER 19, 2023
Intracellular concentration is factor that is not always fully appreciated in chemical biology and I generally recommend that people writing about chemical probes demonstrate awareness of SR2019 (Intracellular and Intraorgan Concentrations of Small Molecule Drugs: Theory, Uncertainties in Infectious Diseases and Oncology, and Promise).
Agency IQ
APRIL 12, 2024
For example, in describing how potency should be demonstrated for CGT products, the 2011 guidance simply stated that potency for gene therapy products is derived from “at least two biological activities for its potency: the ability to transfer a genetic sequence to a cell; and the biological effect of the expressed genetic sequence.”
Expert insights. Personalized for you.
66 
Let's personalize your content