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Biochemical assays and deep cyclic inhibition in cancer treatment

Drug Target Review

Molecular-level biochemical assays like transcriptomics, genomics and proteomics have emerged as valuable tools for identifying potential targets in cancer treatment through deep cyclic inhibition (DCI). Author Bio: Brett Hall Brett has been Chief Scientific Officer at Immuneering since November 2019.

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Target-directed cancer: protein-ligand interactions  

Drug Target Review

We often screen using a biochemical assay, but we can conduct cell-based screening as well. For fragment screening, we can screen with biophysical methods, such as thermal shift assays or, you may have heard about Surface Plasmon Resonance (SPR) which is a very sensitive biophysical technique used for fragment screening.

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Top 10 Drug Discovery Trends at the Top 20 Pharma

PerkinElmer

Industry leaders reveal how high throughput screening is changing in R&D What do you think are the major trends in drug discovery R&D? Biochemical assays have the highest success rate. Which high throughput screening (HTS) approach is the most productive in finding hits for drug development: target-based or phenotypic?

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Analysis Life Sciences Thank You Amid broader shift on LDT policy, FDA unveils pilot program for cancer drug-linked tests and diagnostics

Agency IQ

Further, footnote 7 in the document explains: “Examples of such clinical laboratory tests are commonly used and well understood biochemical assays (e.g., The FDA expects that CDx will be approved with a drug, but that’s not always feasible.

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Article FDA Thank You Draft guidance on potency assays for CGT products garners extensive stakeholder input

Agency IQ

Assays are tests designed to assess various properties (like potency) of chemical or biological samples. The first (pages 1-5) explains what regenerative medicine products are, provides an overview of what “risk management” means, and cites the requirements that drug developers must satisfy per the U.S.