Chemical Biology and Drug Design

JANUARY 23, 2024

Betulinic acid (BA) improved cardiac function, reduced myocardial injury, and attenuated inflammation in the cecal ligation and puncture (CLP) rats, indicating BA as a potential drug for sepsis-induced myocardial dysfunction.

Biochemical Assays 100

Biochemical Assays Protein Expression Drugs Research 100

Sygnature Discovery

MARCH 14, 2025

Employing a comprehensive strategy for hit identification, we use the most effective methods to accurately pinpoint hit series that have the highest potential for evolving into compounds with drug-like properties. These include quality robust assays, reliable automation, secure data, and the quality of the libraries.

Biochemical Assays 52

Biochemical Assays Fragment Screening Computational Chemistry Assay Development 52

Drug Target Review

NOVEMBER 1, 2023

Could you provide an overview of your research on target directed cancer drug discovery, particularly your focus on protein lagging interactions. How do structural biology and biochemical methods play a role in your world? We often screen using a biochemical assay, but we can conduct cell-based screening as well.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

PerkinElmer

FEBRUARY 18, 2021

Industry leaders reveal how high throughput screening is changing in R&D What do you think are the major trends in drug discovery R&D? Biochemical assays have the highest success rate. Here, we summarize the top 10 survey findings on drug discovery trends for the top 20 Pharma leaders in R&D. Think again.

Biochemical Assays 52

Biochemical Assays Drugs Small Molecule Pharma Companies 52

Molecular Design

SEPTEMBER 18, 2024

In the Compatibility Issues section the authors state: Looking beyond laboratory-to-laboratory variability of assays that are nominally the same, there are numerous reasons why literature results for different assays measured against the same “target” may not be comparable.

Biochemical Assays 68

Biochemical Assays Drugs Biophysical Assays Cell Based Assays 68

Molecular Design

JULY 18, 2020

Satchel Paige (1906-1982) The COVID Moonshot and OSC19 are examples of what are sometimes called crowdsourced or open source approaches to drug discovery. Open source drug discovery originated with OSDD in India and it should be noted that the approach has also been pioneered for malaria by OSM.

Biochemical Assays 52

Biochemical Assays Fragment Screening Pharmacokinetics Drugs 52

The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

However, fractured workflows, operational bottlenecks and non-standardized analog data capture has resulted in high cost and slow cycle times that cannot support the urgent and growing demand for new drug discoveries. Strateos’ multi-facility laboratory located in San Diego and Menlo Park, California, which collectively span 14K sq.

Biochemical Assays 52

Biochemical Assays Small Molecule Laboratories Science 52

Practical Cheminformatics

AUGUST 3, 2023

Most papers describing new methods for machine learning (ML) in drug discovery report some sort of benchmark comparing their algorithm and/or molecular representation with the current state of the art. Many authors have simply classified any drugs used for psychiatric indications or drugs with side effects such as drowsiness as CNS penetrant.

Drugs 84

Drugs Biochemical Assays Metabolic Stability Screening Hits 84

Drug Target Review

JANUARY 5, 2024

fowleri cases 3 suggest that combinations of antibiotic and antifungal drugs, including azithromycin, amphotericin B, fluconazole, rifampin and miltefosine (the latter originally formulated for leishmaniasis and cancer chemotherapy 4 ), have a minimal impact on survival. The activity of Z#1334 in inhibiting Nf Ga7 GTPase assay (IC 50 of 2.4

Small Molecule 59

Small Molecule Drugs Biochemical Assays Regulations 59

Molecular Design

DECEMBER 19, 2023

Covalent bond formation between ligands and targets is a drug design tactic for exploiting molecular recognition elements in targets that are difficult to make beneficial contacts with. Carefully designed biochemical assays used in determining IC50 values can be well-suited as surrogates for k.inact/K.i measurements. (

Small Molecule 65

Small Molecule Biochemical Assays Cell Based Assays Drugs 65

Agency IQ

JUNE 26, 2023

In effect, CDx are IVDs (and therefore medical devices) that are specifically intended for use with an accompanying drug or biological product and specifically when the IVD is “essential” for safe and effective use of that drug. But not all tests and diagnostics used with a drug product are actually CDx.

FDA 40

FDA Clinical Trials Laboratories Science 40

Molecular Design

DECEMBER 6, 2023

One criticism that can be made of both BH2010 (original PAINS study) and BW2014 (Chemical con artists foil drug discovery) is that neither study considers the differing implications for drug discovery of these two types of nuisance behavior. In contrast to interference with read-out, an undesirable MoA is a show-stopper.

Biochemical Assays 52

Biochemical Assays Small Molecule Drugs Laboratories 52

Agency IQ

APRIL 12, 2024

Assays are tests designed to assess various properties (like potency) of chemical or biological samples. In addition to assessing binding capabilities, assays can also be used to characterize the activity elicited by a product, whether bound or unbound to the target of interest. Code in order to have their products approved by the FDA.

Production 40

Production FDA Therapies Biochemical Assays 40

Chemical Biology and Drug Design

APRIL 3, 2025

Subsequent rounds of in silico docking, medicinal chemistry optimization, and biochemical assays were performed to increase its potency and selectivity for SRPK3. Six top compounds were identified that displayed single digit micromolar IC 50 values in SRPK3 activity assays and negligible inhibition of SRPK1 or SRPK2.

Biochemical Assays 100

Biochemical Assays Disease Drugs Research 100