Drug Target Review

JULY 12, 2023

Molecular-level biochemical assays like transcriptomics, genomics and proteomics have emerged as valuable tools for identifying potential targets in cancer treatment through deep cyclic inhibition (DCI). This platform can help identify and optimise pharmacologic properties of new drugs.

Biochemical Assays 98

Biochemical Assays Treatment Bioinformatics Disease 98

Drug Target Review

JANUARY 10, 2024

Both are a focus for exciting new small-molecule drug therapeutics that target cancers and autoimmune disorders. The Transcreener HTS Assay platform accelerates these efforts by providing robust and easy-to-use biochemical assays for key enzymes in the pathways.

DNA 104

DNA Biochemical Assays Small Molecule Drugs 104

ASPET

DECEMBER 21, 2023

The incidence of ILDs associated with exposure to multiple hazards, such as inhaled particles, fibers, and ingested soluble chemicals, is increasing yearly, and there are no ideal drugs currently available. Further study revealed that DR3penA may mitigate pulmonary fibrosis by negatively regulating the PI3K/AKT pathway and MAPK pathway.

Biochemical Assays 100

Biochemical Assays Small Molecule Disease Regulations 100

Drug Target Review

NOVEMBER 1, 2023

Could you provide an overview of your research on target directed cancer drug discovery, particularly your focus on protein lagging interactions. How do structural biology and biochemical methods play a role in your world? We often screen using a biochemical assay, but we can conduct cell-based screening as well.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Covalent Modifiers

MARCH 17, 2023

2c12781 Molecules that stabilize protein–protein interactions (PPIs) are invaluable as tool compounds for biophysics and (structural) biology, and as starting points for molecular glue drug discovery. Based on a focused library of dual-reactive small molecules, a molecular glue tool compound was rapidly developed.

Biochemical Assays 52

Biochemical Assays Small Molecule Drugs 52

The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

However, fractured workflows, operational bottlenecks and non-standardized analog data capture has resulted in high cost and slow cycle times that cannot support the urgent and growing demand for new drug discoveries. Strateos’ multi-facility laboratory located in San Diego and Menlo Park, California, which collectively span 14K sq.

Biochemical Assays 52

Biochemical Assays Small Molecule Laboratories Science 52

PerkinElmer

FEBRUARY 18, 2021

Industry leaders reveal how high throughput screening is changing in R&D What do you think are the major trends in drug discovery R&D? Small screens are better than large ones. Biochemical assays have the highest success rate. Top 10 trends in pre-clinical drug discovery at top 20 Pharma 1. Think again.

Biochemical Assays 52

Biochemical Assays Drugs Small Molecule Pharma Companies 52