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In terms of compound libraries, we have a high-throughput screening library of about 200,000 ligands. For fragmentscreening, which are much smaller compounds, we have a library of about 3000 fragments. We can screen with many different formats and modalities.
It’s also worth mentioning that fragmentscreens have been run against SARS-CoV-2 Nsp3 macrodomain at UCSF and Diamond since there are no known inhibitors for this target. This is one reason that biophysical detection of binding using methods such as surface plasmon resonance (SPR) are favored in fragment-based lead discovery.
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