Drug Target Review

JULY 12, 2023

Molecular-level biochemical assays like transcriptomics, genomics and proteomics have emerged as valuable tools for identifying potential targets in cancer treatment through deep cyclic inhibition (DCI). We are pleased that to date our lead product candidate has aligned DCI profiles as expected.

Biochemical Assays 98

Biochemical Assays Treatment Bioinformatics Disease 98

Chemical Biology and Drug Design

MAY 17, 2024

While the excess production of melanin causes hyperpigmentation of human skin, hypopigmentation results in medical conditions like vitiligo. Using fungal tyrosinase-based in vitro biochemical assay, we obtained one compound ( 3k ) which could inhibit tyrosinase activity, and the other compound ( 4f ) that stimulated tyrosinase activity.

Biochemical Assays 100

Biochemical Assays Regulations Production Research 100

Sygnature Discovery

MARCH 14, 2025

Compounds are drug-like with high chirality and FSP3 and the library contains novel natural product inspired scaffolds. Advanced Automation in Sygnature Discoverys HTS System Our high throughput screening system, developed by HighRes Biosolutions, is designed for versatility, accommodating both cell and biochemical assays.

Biochemical Assays 52

Biochemical Assays Fragment Screening Computational Chemistry Assay Development 52

Drug Target Review

NOVEMBER 1, 2023

We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production. We often screen using a biochemical assay, but we can conduct cell-based screening as well. We need to build the assays that we need for compound screening.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

PerkinElmer

FEBRUARY 18, 2021

Biochemical assays have the highest success rate. To lead in product development and partner with customers in solving everyday challenges, we gather information regularly about current practices and future trends,” said Volker Eckelt, PhD, Senior Strategy Leader, PerkinElmer Life Sciences. “To Biologics are booming.

Biochemical Assays 52

Biochemical Assays Drugs Small Molecule Pharma Companies 52

The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

Daniel will discuss key learnings and results of automating the DMTA cycle after over a year operating in production mode,  including the reduction of researchers’ hands-on time by 90%, ability to screen 1M+ molecules in as little as two weeks to identify lead scaffolds, and automated reproducible synthesis of compounds followed by downstream (..)

Biochemical Assays 52

Biochemical Assays Small Molecule Laboratories Science 52

Agency IQ

APRIL 12, 2024

Draft guidance on potency assays for CGT products garners extensive stakeholder input Late last year, the FDA published a draft update to its 2011 guidance on potency assays for cell and gene therapy products, unveiling a major shift in approach to the issue.

Production 40

Production FDA Therapies Biochemical Assays 40