Chemical Biology and Drug Design

FEBRUARY 3, 2025

The invitro biochemical assays validated that J1-65 inhibits PTP-PEST activity competitively and the inhibitor binding stabilizes the protein-ligand complex. ABSTRACT PTP-PEST (also known as PTPN12) regulates cellular signaling and transduction pathways by dephosphorylating its substrate.

Small Molecule 100

Small Molecule Biochemical Assays Regulations Drugs 100

Chemical Biology and Drug Design

MAY 17, 2024

Among a wide range of tyrosinase-regulating compounds, natural and synthetic derivatives of furochromenones, such as 8-methoxypsoralen (8-MOP), are known to both activate and inhibit tyrosinase. In the present study, we investigated these compounds for their potential as antagonists or agonists of tyrosinase.

Biochemical Assays 100

Biochemical Assays Regulations Production Research 100

ASPET

DECEMBER 21, 2023

Our previous research showed that the novel and low-toxicity peptide DR3penA had a strong antifibrotic effect on a bleomycin-induced murine model. Further study revealed that DR3penA may mitigate pulmonary fibrosis by negatively regulating the PI3K/AKT pathway and MAPK pathway.

Biochemical Assays 100

Biochemical Assays Small Molecule Disease Regulations 100

Drug Target Review

DECEMBER 8, 2023

Researchers from the Bon-Kyoung Koo laboratory at the Institute of Molecular Biotechnology (IMBA) and the Institute for Basic Science have used intestinal organoids to find a new gene, Daam1, that plays an essential role in switching on the development of secretory cells in the intestine. This opens new opportunities in cancer research.

Biochemical Assays 59

Biochemical Assays Regulations Science Laboratories 59

Agency IQ

JUNE 26, 2023

Because CDx are diagnostic devices, they are not considered part of a combination product but are regulated separately as medical devices. Further, footnote 7 in the document explains: “Examples of such clinical laboratory tests are commonly used and well understood biochemical assays (e.g.,

FDA 40

FDA Clinical Trials Laboratories Science 40

Agency IQ

APRIL 12, 2024

BY RACHEL COE, MSC | APR 11, 2024 1:06 PM CDT Regulatory background: Product potency and assays As defined in statute , the FDA uses the term “potency” to refer to the “specific ability or capability” of a product to “effect a given result.” for gene therapies that use viral or nonviral vectors).

Production 40

Production FDA Therapies Biochemical Assays 40

Drug Target Review

JANUARY 5, 2024

Researchers and clinicians suggest two key barriers to surviving a N. Å resolution) 6 is now being targeted for small molecule inhibitor discovery and development, by exploiting emergent computational tools to identify potential candidate compounds in silico and then test these predicted inhibitors in in vitro biochemical assays.

Small Molecule 59

Small Molecule Drugs Biochemical Assays Regulations 59